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Identification of Key Residues That Confer Rhodobacter sphaeroides LPS Activity at Horse TLR4/MD-2

The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4) are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises d...

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Detalles Bibliográficos
Autores principales: Irvine, Katherine L., Gangloff, Monique, Walsh, Catherine M., Spring, David R., Gay, Nicholas J., Bryant, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039514/
https://www.ncbi.nlm.nih.gov/pubmed/24879320
http://dx.doi.org/10.1371/journal.pone.0098776