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Update on the pathogenic potential and treatment options for Blastocystis sp

Although Blastocystis is one of the most common enteric parasites, there is still much controversy surrounding the pathogenicity and potential treatment options for this parasite. In this review we look at the evidence supporting Blastocystis as an intestinal pathogen as shown by numerous case studi...

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Autores principales: Roberts, Tamalee, Stark, Damien, Harkness, John, Ellis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039988/
https://www.ncbi.nlm.nih.gov/pubmed/24883113
http://dx.doi.org/10.1186/1757-4749-6-17
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author Roberts, Tamalee
Stark, Damien
Harkness, John
Ellis, John
author_facet Roberts, Tamalee
Stark, Damien
Harkness, John
Ellis, John
author_sort Roberts, Tamalee
collection PubMed
description Although Blastocystis is one of the most common enteric parasites, there is still much controversy surrounding the pathogenicity and potential treatment options for this parasite. In this review we look at the evidence supporting Blastocystis as an intestinal pathogen as shown by numerous case studies and several in vivo studies and the evidence against. We describe the chronic nature of some infections and show the role of Blastocystis in immunocompromised patients and the relationship between irritable bowel syndrome and Blastocystis infection. There have been several studies that have suggested that pathogenicity may be subtype related. Metronidazole is the most widely accepted treatment for Blastocystis but several cases of treatment failure and resistance have been described. Other treatment options which have been suggested include paromomycin and trimethroprim- sulfamethoxazole.
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spelling pubmed-40399882014-06-01 Update on the pathogenic potential and treatment options for Blastocystis sp Roberts, Tamalee Stark, Damien Harkness, John Ellis, John Gut Pathog Review Although Blastocystis is one of the most common enteric parasites, there is still much controversy surrounding the pathogenicity and potential treatment options for this parasite. In this review we look at the evidence supporting Blastocystis as an intestinal pathogen as shown by numerous case studies and several in vivo studies and the evidence against. We describe the chronic nature of some infections and show the role of Blastocystis in immunocompromised patients and the relationship between irritable bowel syndrome and Blastocystis infection. There have been several studies that have suggested that pathogenicity may be subtype related. Metronidazole is the most widely accepted treatment for Blastocystis but several cases of treatment failure and resistance have been described. Other treatment options which have been suggested include paromomycin and trimethroprim- sulfamethoxazole. BioMed Central 2014-05-28 /pmc/articles/PMC4039988/ /pubmed/24883113 http://dx.doi.org/10.1186/1757-4749-6-17 Text en Copyright © 2014 Roberts et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Roberts, Tamalee
Stark, Damien
Harkness, John
Ellis, John
Update on the pathogenic potential and treatment options for Blastocystis sp
title Update on the pathogenic potential and treatment options for Blastocystis sp
title_full Update on the pathogenic potential and treatment options for Blastocystis sp
title_fullStr Update on the pathogenic potential and treatment options for Blastocystis sp
title_full_unstemmed Update on the pathogenic potential and treatment options for Blastocystis sp
title_short Update on the pathogenic potential and treatment options for Blastocystis sp
title_sort update on the pathogenic potential and treatment options for blastocystis sp
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039988/
https://www.ncbi.nlm.nih.gov/pubmed/24883113
http://dx.doi.org/10.1186/1757-4749-6-17
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