Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 lysine 27 trimethylation

Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-ALL)(1) and polysomy 21 is the most frequent somatic aneuploidy amongst all B-ALLs(2). Yet, the mechanistic links between chr.21 triplication and B-ALL remain undefined. Here we show that germline triplication o...

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Detalles Bibliográficos
Autores principales: Lane, Andrew A., Chapuy, Bjoern, Lin, Charles Y., Tivey, Trevor, Li, Hubo, Townsend, Elizabeth C., van Bodegom, Diederik, Day, Tovah A., Wu, Shuo-Chieh, Liu, Huiyun, Yoda, Akinori, Alexe, Gabriela, Schinzel, Anna C., Sullivan, Timothy J., Malinge, Sébastien, Taylor, Jordan E., Stegmaier, Kimberly, Jaffe, Jacob D., Bustin, Michael, te Kronnie, Geertruy, Izraeli, Shai, Harris, Marian, Stevenson, Kristen E., Neuberg, Donna, Silverman, Lewis B., Sallan, Stephen E., Bradner, James E., Hahn, William C., Crispino, John D., Pellman, David, Weinstock, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040006/
https://www.ncbi.nlm.nih.gov/pubmed/24747640
http://dx.doi.org/10.1038/ng.2949

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