Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and suppressing protein synthesis. Caloric restriction or rapamycin extends murine lifespan and ameliorates many aging-associated disorders; however, the benefic...

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Detalles Bibliográficos
Autores principales: Dai, Dao-Fu, Karunadharma, Pabalu P, Chiao, Ying A, Basisty, Nathan, Crispin, David, Hsieh, Edward J, Chen, Tony, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Beyer, Richard P, MacCoss, Michael J, Rabinovitch, Peter S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040127/
https://www.ncbi.nlm.nih.gov/pubmed/24612461
http://dx.doi.org/10.1111/acel.12203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040127/
https://www.ncbi.nlm.nih.gov/pubmed/24612461
http://dx.doi.org/10.1111/acel.12203

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