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Does Adding Dexamethasone to Clomiphene Citrate Improve Ovulation in PCOS Patients? A Triple - Blind Randomized Clinical Trial Study
BACKGROUND: A common cause of anovulation is polycystic ovarian syndrome (PCOS). Clomiphene citrate (CC) is the first line of treatment in PCOS patients however approximately 25% of patients may be CC-resistant. This study aimed to evaluate the efficacy of adding dexamethasone (dex) to CC in CC-resi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040244/ https://www.ncbi.nlm.nih.gov/pubmed/24917918 |
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author | Esmaeilzadeh, Seddigheh Amiri, Masoumeh Golsorkhtabar Basirat, Zahra Shirazi, Mahin |
author_facet | Esmaeilzadeh, Seddigheh Amiri, Masoumeh Golsorkhtabar Basirat, Zahra Shirazi, Mahin |
author_sort | Esmaeilzadeh, Seddigheh |
collection | PubMed |
description | BACKGROUND: A common cause of anovulation is polycystic ovarian syndrome (PCOS). Clomiphene citrate (CC) is the first line of treatment in PCOS patients however approximately 25% of patients may be CC-resistant. This study aimed to evaluate the efficacy of adding dexamethasone (dex) to CC in CC-resistant PCOS patients with the intent to improve ovulation. MATERIALS AND METHODS: This randomized controlled trial study was performed on 60 infertile PCOS patients referred to our infertility research center from 2007 to 2009. Patients were randomly divided in two groups and stimulation performed with dex+CC or CC+placebo. Rates of ovulation, pregnancy and number of mature follicles were evaluated. RESULTS: Ovulation rate in the dex+CC group was 21 out of 30 (70%) and in the CC+placebo group it was 17 out of 30 (56.7%). The pregnancy rate was 5 (16.7%) in the dex+CC group and 3 (10%) in the CC+placebo group. There was no significant difference between rates of ovulation and pregnancy in both groups, but the number of follicles ≥18 mm were significant in the dex+CC group (p<0.05). CONCLUSION: Our results showed that addition of dex to CC significantly increased the number of matured follicles, however the ovulation and pregnancy rates were comparable between the two groups (Registeration Number: IRCT 138807041760 N2). |
format | Online Article Text |
id | pubmed-4040244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-40402442014-06-10 Does Adding Dexamethasone to Clomiphene Citrate Improve Ovulation in PCOS Patients? A Triple - Blind Randomized Clinical Trial Study Esmaeilzadeh, Seddigheh Amiri, Masoumeh Golsorkhtabar Basirat, Zahra Shirazi, Mahin Int J Fertil Steril Original Article BACKGROUND: A common cause of anovulation is polycystic ovarian syndrome (PCOS). Clomiphene citrate (CC) is the first line of treatment in PCOS patients however approximately 25% of patients may be CC-resistant. This study aimed to evaluate the efficacy of adding dexamethasone (dex) to CC in CC-resistant PCOS patients with the intent to improve ovulation. MATERIALS AND METHODS: This randomized controlled trial study was performed on 60 infertile PCOS patients referred to our infertility research center from 2007 to 2009. Patients were randomly divided in two groups and stimulation performed with dex+CC or CC+placebo. Rates of ovulation, pregnancy and number of mature follicles were evaluated. RESULTS: Ovulation rate in the dex+CC group was 21 out of 30 (70%) and in the CC+placebo group it was 17 out of 30 (56.7%). The pregnancy rate was 5 (16.7%) in the dex+CC group and 3 (10%) in the CC+placebo group. There was no significant difference between rates of ovulation and pregnancy in both groups, but the number of follicles ≥18 mm were significant in the dex+CC group (p<0.05). CONCLUSION: Our results showed that addition of dex to CC significantly increased the number of matured follicles, however the ovulation and pregnancy rates were comparable between the two groups (Registeration Number: IRCT 138807041760 N2). Royan Institute 2011 2011-03-21 /pmc/articles/PMC4040244/ /pubmed/24917918 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Esmaeilzadeh, Seddigheh Amiri, Masoumeh Golsorkhtabar Basirat, Zahra Shirazi, Mahin Does Adding Dexamethasone to Clomiphene Citrate Improve Ovulation in PCOS Patients? A Triple - Blind Randomized Clinical Trial Study |
title | Does Adding Dexamethasone to Clomiphene Citrate Improve
Ovulation in PCOS Patients? A Triple - Blind Randomized
Clinical Trial Study |
title_full | Does Adding Dexamethasone to Clomiphene Citrate Improve
Ovulation in PCOS Patients? A Triple - Blind Randomized
Clinical Trial Study |
title_fullStr | Does Adding Dexamethasone to Clomiphene Citrate Improve
Ovulation in PCOS Patients? A Triple - Blind Randomized
Clinical Trial Study |
title_full_unstemmed | Does Adding Dexamethasone to Clomiphene Citrate Improve
Ovulation in PCOS Patients? A Triple - Blind Randomized
Clinical Trial Study |
title_short | Does Adding Dexamethasone to Clomiphene Citrate Improve
Ovulation in PCOS Patients? A Triple - Blind Randomized
Clinical Trial Study |
title_sort | does adding dexamethasone to clomiphene citrate improve
ovulation in pcos patients? a triple - blind randomized
clinical trial study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040244/ https://www.ncbi.nlm.nih.gov/pubmed/24917918 |
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