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Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex

In both humans and rodents, decline in cognitive function is a hallmark of the aging process; the basis for this decrease has yet to be fully characterized. However, using aged rodent models, deficits in auditory processing have been associated with significant decreases in inhibitory signaling attr...

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Autores principales: Ouellet, Lydia, de Villers-Sidani, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040493/
https://www.ncbi.nlm.nih.gov/pubmed/24917792
http://dx.doi.org/10.3389/fnana.2014.00040
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author Ouellet, Lydia
de Villers-Sidani, Etienne
author_facet Ouellet, Lydia
de Villers-Sidani, Etienne
author_sort Ouellet, Lydia
collection PubMed
description In both humans and rodents, decline in cognitive function is a hallmark of the aging process; the basis for this decrease has yet to be fully characterized. However, using aged rodent models, deficits in auditory processing have been associated with significant decreases in inhibitory signaling attributed to a loss of GABAergic interneurons. Not only are these interneurons crucial for pattern detection and other large-scale population dynamics, but they have also been linked to mechanisms mediating plasticity and learning, making them a prime candidate for study and modeling of modifications to cortical communication pathways in neurodegenerative diseases. Using the rat primary auditory cortex (A1) as a model, we probed the known markers of GABAergic interneurons with immunohistological methods, using antibodies against gamma aminobutyric acid (GABA), parvalbumin (PV), somatostatin (SOM), calretinin (CR), vasoactive intestinal peptide (VIP), choline acetyltransferase (ChAT), neuropeptide Y (NPY), and cholecystokinin (CCK) to document the changes observed in interneuron populations across the rat's lifespan. This analysis provided strong evidence that several but not all GABAergic neurons were affected by the aging process, showing most dramatic changes in expression of parvalbumin (PV) and somatostatin (SOM) expression. With this evidence, we show how understanding these trajectories of cell counts may be factored into a simple model to quantify changes in inhibitory signaling across the course of life, which may be applied as a framework for creating more advanced simulations of interneuronal implication in normal cerebral processing, normal aging, or pathological processes.
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spelling pubmed-40404932014-06-10 Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex Ouellet, Lydia de Villers-Sidani, Etienne Front Neuroanat Neuroscience In both humans and rodents, decline in cognitive function is a hallmark of the aging process; the basis for this decrease has yet to be fully characterized. However, using aged rodent models, deficits in auditory processing have been associated with significant decreases in inhibitory signaling attributed to a loss of GABAergic interneurons. Not only are these interneurons crucial for pattern detection and other large-scale population dynamics, but they have also been linked to mechanisms mediating plasticity and learning, making them a prime candidate for study and modeling of modifications to cortical communication pathways in neurodegenerative diseases. Using the rat primary auditory cortex (A1) as a model, we probed the known markers of GABAergic interneurons with immunohistological methods, using antibodies against gamma aminobutyric acid (GABA), parvalbumin (PV), somatostatin (SOM), calretinin (CR), vasoactive intestinal peptide (VIP), choline acetyltransferase (ChAT), neuropeptide Y (NPY), and cholecystokinin (CCK) to document the changes observed in interneuron populations across the rat's lifespan. This analysis provided strong evidence that several but not all GABAergic neurons were affected by the aging process, showing most dramatic changes in expression of parvalbumin (PV) and somatostatin (SOM) expression. With this evidence, we show how understanding these trajectories of cell counts may be factored into a simple model to quantify changes in inhibitory signaling across the course of life, which may be applied as a framework for creating more advanced simulations of interneuronal implication in normal cerebral processing, normal aging, or pathological processes. Frontiers Media S.A. 2014-06-02 /pmc/articles/PMC4040493/ /pubmed/24917792 http://dx.doi.org/10.3389/fnana.2014.00040 Text en Copyright © 2014 Ouellet and de Villers-Sidani. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ouellet, Lydia
de Villers-Sidani, Etienne
Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex
title Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex
title_full Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex
title_fullStr Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex
title_full_unstemmed Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex
title_short Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex
title_sort trajectory of the main gabaergic interneuron populations from early development to old age in the rat primary auditory cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040493/
https://www.ncbi.nlm.nih.gov/pubmed/24917792
http://dx.doi.org/10.3389/fnana.2014.00040
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