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Prevalence of HPV infection and other risk factors in a Fijian population
BACKGROUND: Cancer is among the leading contributors to morbidity and mortality in the Pacific, but the magnitude of the problem and the potential for prevention have not been comprehensively studied. Over the past decade, cervical cancer has been the most common cancer among women in Fiji with an a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040509/ https://www.ncbi.nlm.nih.gov/pubmed/24891876 http://dx.doi.org/10.1186/1750-9378-9-14 |
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author | Foliaki, Sunia Brewer, Naomi Pearce, Neil Snijders, Peter JF Meijer, Chris JLM Waqatakirewa, Lepani Clifford, Gary M Franceschi, Silvia |
author_facet | Foliaki, Sunia Brewer, Naomi Pearce, Neil Snijders, Peter JF Meijer, Chris JLM Waqatakirewa, Lepani Clifford, Gary M Franceschi, Silvia |
author_sort | Foliaki, Sunia |
collection | PubMed |
description | BACKGROUND: Cancer is among the leading contributors to morbidity and mortality in the Pacific, but the magnitude of the problem and the potential for prevention have not been comprehensively studied. Over the past decade, cervical cancer has been the most common cancer among women in Fiji with an age standardised cervical cancer incidence rate of 51 per 100,000. This rate is among the highest in the South Pacific region and in the world. This high cervical cancer incidence rate is likely linked to the low cervical screening rate, but it points also to the possibility of a high burden of human papillomavirus (HPV) infection. METHODS: We conducted a population-based survey in Fiji to provide information on human papillomavirus (HPV) prevalence, and the distribution of individual HPV types in a Fijian health-sub-district. We included 1,261 women aged between 16 and 64 years. A general primer GP5+/6+ mediatedpolymerase chain reaction (PCR) assay was used for HPV testing of 44 HPV types. RESULTS: The crude HPV prevalence in 1,244 women with an adequate HPV sample was 24.0% (95% confidence interval (CI), 21.7-26.4%) and the corresponding age standardised prevalence was 25.5% (95% CI, 23.1-28.1%). The prevalence of high-risk HPV types was 13.6% (95% CI, 11.8-15.6%). Among 1,192 women with adequate cytological results, 13 (1.1%) showed cervical abnormalities, the majority of which were high-grade intraepithelial lesions or worse. HPV prevalence declined from 35.8% in women aged <25 years to 18.6% in those aged 55–64 years of age. After adjustment, the only variables significantly associated with HPV-positivity were age (ranging from odds ratio (OR) 0.57 (95% CI, 0.36-0.89) for 25–34 year-old-women to OR 0.43 (95% CI, 0.20-0.89) for 55–64 year-old-women) and ‘husband’s extramarital sexual relationships’ (OR 1.69; 95% CI, 1.17-2.34). CONCLUSION: These findings on HPV provide key information for future policy decisions on the most appropriate methods of cervical cancer prevention in Fiji and in the Pacific region. |
format | Online Article Text |
id | pubmed-4040509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40405092014-06-03 Prevalence of HPV infection and other risk factors in a Fijian population Foliaki, Sunia Brewer, Naomi Pearce, Neil Snijders, Peter JF Meijer, Chris JLM Waqatakirewa, Lepani Clifford, Gary M Franceschi, Silvia Infect Agent Cancer Research Article BACKGROUND: Cancer is among the leading contributors to morbidity and mortality in the Pacific, but the magnitude of the problem and the potential for prevention have not been comprehensively studied. Over the past decade, cervical cancer has been the most common cancer among women in Fiji with an age standardised cervical cancer incidence rate of 51 per 100,000. This rate is among the highest in the South Pacific region and in the world. This high cervical cancer incidence rate is likely linked to the low cervical screening rate, but it points also to the possibility of a high burden of human papillomavirus (HPV) infection. METHODS: We conducted a population-based survey in Fiji to provide information on human papillomavirus (HPV) prevalence, and the distribution of individual HPV types in a Fijian health-sub-district. We included 1,261 women aged between 16 and 64 years. A general primer GP5+/6+ mediatedpolymerase chain reaction (PCR) assay was used for HPV testing of 44 HPV types. RESULTS: The crude HPV prevalence in 1,244 women with an adequate HPV sample was 24.0% (95% confidence interval (CI), 21.7-26.4%) and the corresponding age standardised prevalence was 25.5% (95% CI, 23.1-28.1%). The prevalence of high-risk HPV types was 13.6% (95% CI, 11.8-15.6%). Among 1,192 women with adequate cytological results, 13 (1.1%) showed cervical abnormalities, the majority of which were high-grade intraepithelial lesions or worse. HPV prevalence declined from 35.8% in women aged <25 years to 18.6% in those aged 55–64 years of age. After adjustment, the only variables significantly associated with HPV-positivity were age (ranging from odds ratio (OR) 0.57 (95% CI, 0.36-0.89) for 25–34 year-old-women to OR 0.43 (95% CI, 0.20-0.89) for 55–64 year-old-women) and ‘husband’s extramarital sexual relationships’ (OR 1.69; 95% CI, 1.17-2.34). CONCLUSION: These findings on HPV provide key information for future policy decisions on the most appropriate methods of cervical cancer prevention in Fiji and in the Pacific region. BioMed Central 2014-04-28 /pmc/articles/PMC4040509/ /pubmed/24891876 http://dx.doi.org/10.1186/1750-9378-9-14 Text en Copyright © 2014 Foliaki et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Foliaki, Sunia Brewer, Naomi Pearce, Neil Snijders, Peter JF Meijer, Chris JLM Waqatakirewa, Lepani Clifford, Gary M Franceschi, Silvia Prevalence of HPV infection and other risk factors in a Fijian population |
title | Prevalence of HPV infection and other risk factors in a Fijian population |
title_full | Prevalence of HPV infection and other risk factors in a Fijian population |
title_fullStr | Prevalence of HPV infection and other risk factors in a Fijian population |
title_full_unstemmed | Prevalence of HPV infection and other risk factors in a Fijian population |
title_short | Prevalence of HPV infection and other risk factors in a Fijian population |
title_sort | prevalence of hpv infection and other risk factors in a fijian population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040509/ https://www.ncbi.nlm.nih.gov/pubmed/24891876 http://dx.doi.org/10.1186/1750-9378-9-14 |
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