Cargando…

Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma

Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm with transient response to conventional chemotherapy. We here investigated the role of the Bcl-2 homology domain 3-only protein NOXA for life–death decision in MCL. Surprisingly, NOXA (PMAIP1) mRNA and NOXA protein levels were extremely d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dengler, M A, Weilbacher, A, Gutekunst, M, Staiger, A M, Vöhringer, M C, Horn, H, Ott, G, Aulitzky, W E, van der Kuip, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040662/ https://www.ncbi.nlm.nih.gov/pubmed/24457957 http://dx.doi.org/10.1038/cddis.2013.552

Ejemplares similares

Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA
por: Heine, Simon, et al.
Publicado: (2018)

A Polymorphism Located Near PMAIP1/Noxa Gene Influences Susceptibility to Hodgkin Lymphoma Development in South India
por: Thakkar, Dimpal N, et al.
Publicado: (2017)

Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma
por: Leshchenko, Violetta V., et al.
Publicado: (2015)

Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia
por: Cojocari, Dan, et al.
Publicado: (2021)

RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38
por: Weilbacher, A, et al.
Publicado: (2014)

NOXA as critical mediator for drug combinations in polychemotherapy
por: Ehrhardt, H, et al.
Publicado: (2012)

p53 Hypersensitivity Is the Predominant Mechanism of the Unique Responsiveness of Testicular Germ Cell Tumor (TGCT) Cells to Cisplatin
por: Gutekunst, Matthias, et al.
Publicado: (2011)

Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation
por: Karim, Christine B., et al.
Publicado: (2015)

Aspirin Induced Glioma Apoptosis through Noxa Upregulation
por: Chang, Cheng-Yi, et al.
Publicado: (2020)

NOXA Is Important for Verticillium dahliae’s Penetration Ability and Virulence
por: Zhu, Xiaohan, et al.
Publicado: (2021)

NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor
por: Ashry, Ramy, et al.
Publicado: (2023)

Erratum: Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation
por: Karim, Christine B., et al.
Publicado: (2015)

BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis
por: Wensveen, Felix M., et al.
Publicado: (2013)

Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA
por: Fairchild, Carter K., et al.
Publicado: (2021)

The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA
por: Weller, Sandra, et al.
Publicado: (2022)

BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma
por: Busacca, Sara, et al.
Publicado: (2013)

Oncogenic Stress Induced by Acute Hyper-Activation of Bcr-Abl Leads to Cell Death upon Induction of Excessive Aerobic Glycolysis
por: Dengler, Michael A., et al.
Publicado: (2011)

Pituitary adenomas evade apoptosis via noxa deregulation in Cushing’s disease
por: Asuzu, David T., et al.
Publicado: (2022)

Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa
por: de Bruijn, M T, et al.
Publicado: (2010)

Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin
por: Escobar, D, et al.
Publicado: (2015)

Induction of Noxa-Mediated Apoptosis by Modified Vaccinia Virus Ankara Depends on Viral Recognition by Cytosolic Helicases, Leading to IRF-3/IFN-β-Dependent Induction of Pro-Apoptotic Noxa
por: Eitz Ferrer, Pedro, et al.
Publicado: (2011)

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer
por: Doffo, Josefina, et al.
Publicado: (2022)

The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression
por: Lynch, James T, et al.
Publicado: (2010)

Expression of Bim, Noxa, and Puma in non-small cell lung cancer
por: Sakakibara-Konishi, Jun, et al.
Publicado: (2012)

BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis
por: Delannoy, Aurélie, et al.
Publicado: (2018)

SAT-300 Evading Death: Noxa in Cushing’s Disease Pituitary Adenomas
por: Alvarez, Reinier, et al.
Publicado: (2020)

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
por: Montero, Joan, et al.
Publicado: (2019)

Correction: BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma
por: Busacca, Sara, et al.
Publicado: (2013)

Anti-Tumoral Effect of the Mitochondrial Target Domain of Noxa Delivered by an Engineered Salmonella typhimurium
por: Jeong, Jae-Ho, et al.
Publicado: (2014)

Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B
por: Martin, Angel G., et al.
Publicado: (2009)

Commentary: Achilles' heel
por: Cook, Chris C., et al.
Publicado: (2020)

Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1
por: Wensveen, Felix M., et al.
Publicado: (2011)

MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal Inhibitors
por: Lerner, Mikael, et al.
Publicado: (2012)

The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest
por: Haschka, Manuel D., et al.
Publicado: (2015)

Pro‐apoptotic Noxa is involved in ablative focal irradiation‐induced lung injury
por: Kim, Jee‐Youn, et al.
Publicado: (2016)

Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy
por: Albert, Marie-Christine, et al.
Publicado: (2014)

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage
por: Albert, Marie-Christine, et al.
Publicado: (2020)

BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced Apoptosis
por: Roufayel, Rabih, et al.
Publicado: (2022)

The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin
por: Geserick, P, et al.
Publicado: (2014)

The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin
por: Geserick, P, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_8ob2vmcufcdj9dkgjeteqna145