Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/TNFSF10/Apo2L) holds promise for cancer therapy as it induces apoptosis in a large variety of cancer cells while exerting negligible toxicity in normal ones. However, TRAIL can also induce proliferative and migratory signaling in cancer...

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Detalles Bibliográficos
Autores principales: Pavet, V, Shlyakhtina, Y, He, T, Ceschin, D G, Kohonen, P, Perälä, M, Kallioniemi, O, Gronemeyer, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040674/
https://www.ncbi.nlm.nih.gov/pubmed/24481457
http://dx.doi.org/10.1038/cddis.2014.5

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