Pro-apoptotic Sorafenib signaling in murine hepatocytes depends on malignancy and is associated with PUMA expression in vitro and in vivo

The multi-kinase inhibitor Sorafenib increases the survival of patients with advanced hepatocellular carcinoma (HCC). Current data suggest that Sorafenib inhibits cellular proliferation and angiogenesis and promotes apoptosis. However, the underlying pro-apoptotic molecular mechanisms are incomplete...

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Detalles Bibliográficos
Autores principales: Sonntag, R, Gassler, N, Bangen, J-M, Trautwein, C, Liedtke, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040679/
https://www.ncbi.nlm.nih.gov/pubmed/24481444
http://dx.doi.org/10.1038/cddis.2013.557

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