CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants

To combine the CD27 stimulation inhibitory effect of blocking CD70 antibodies with an antibody-dependent cellular cytotoxicity (ADCC)-independent, cell death-inducing activity for targeting of CD70-expressing tumors, we evaluated here fusion proteins of the apoptosis-inducing TNF family member TRAIL...

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Detalles Bibliográficos
Autores principales: Trebing, J, El-Mesery, M, Schäfer, V, Weisenberger, D, Siegmund, D, Silence, K, Wajant, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040681/
https://www.ncbi.nlm.nih.gov/pubmed/24481449
http://dx.doi.org/10.1038/cddis.2013.555

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