Association of p21 with NF-YA suppresses the expression of Polo-like kinase 1 and prevents mitotic death in response to DNA damage

Polo-like kinase 1 (PLK1) is an important mitotic kinase and its expression is tightly regulated in the cell cycle and in the DNA damage response. PLK1 expression is previously shown to be suppressed by p53 and/or p21. Here, we demonstrate that the CCAAT box in the PLK1 promoter is pivotal for p53/p...

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Detalles Bibliográficos
Autores principales: Lin, Y-C, Chen, Y-N, Lin, K-F, Wang, F-F, Chou, T-Y, Chen, M-Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040702/
https://www.ncbi.nlm.nih.gov/pubmed/24407240
http://dx.doi.org/10.1038/cddis.2013.527

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