RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo

R-(−)-gossypol acetic acid (AT-101) is a natural cottonseed product that exhibits anticancer activity. However, the molecular mechanism behind the antileukemic activity of AT-101 has not been well characterized. In this study, we investigated how AT-101 induces apoptosis in human leukemia cells. Exp...

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Detalles Bibliográficos
Autores principales: Li, G, Liu, L, Shan, C, Cheng, Q, Budhraja, A, Zhou, T, Cui, H, Gao, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040709/
https://www.ncbi.nlm.nih.gov/pubmed/24434521
http://dx.doi.org/10.1038/cddis.2013.519

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