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Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 – implications for dementia with Lewy bodies
BACKGROUND: In dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum. However, factors rendering these neurons selectively vulnerable have not been fully investi...
Autores principales: | Overk, Cassia R, Cartier, Anna, Shaked, Gideon, Rockenstein, Edward, Ubhi, Kiren, Spencer, Brian, Price, Diana L, Patrick, Christina, Desplats, Paula, Masliah, Eliezer |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041038/ https://www.ncbi.nlm.nih.gov/pubmed/24885390 http://dx.doi.org/10.1186/1750-1326-9-18 |
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