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Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation

STUDY OBJECTIVES: We proposed that mice supplemented with quercetin, a class of flavonoids known to have antioxidant and anti-inflammatory properties, will have profound effects on the pathophysiology of atherosclerosis when combined with exercise. STUDY DESIGN: Forty C57BL6 LDLr −/− mice were divid...

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Autores principales: Garelnabi, Mahdi, Mahini, Halleh, Wilson, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041042/
https://www.ncbi.nlm.nih.gov/pubmed/24890098
http://dx.doi.org/10.1186/1550-2783-11-22
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author Garelnabi, Mahdi
Mahini, Halleh
Wilson, Thomas
author_facet Garelnabi, Mahdi
Mahini, Halleh
Wilson, Thomas
author_sort Garelnabi, Mahdi
collection PubMed
description STUDY OBJECTIVES: We proposed that mice supplemented with quercetin, a class of flavonoids known to have antioxidant and anti-inflammatory properties, will have profound effects on the pathophysiology of atherosclerosis when combined with exercise. STUDY DESIGN: Forty C57BL6 LDLr −/− mice were divided into four groups (n = 10): control untreated (NN); control group supplemented with 100 μg/day of quercetin (NQ); exercise group (EN); and exercise group supplemented with 100 μg/day of quercetin (EQ). All animals were fed atherogenic diet. The exercise groups were run on a treadmill for 30 minutes, 15 m/min for 5 days/week for 30 days. After 30 day animals were sacrificed and tissues were harvested. RESULTS AND CONCLUSION: Mice supplemented with quercetin during exercise sessions had 78% atherosclerotic plaque reduction compared to control mice and 40% less atherosclerotic plaque formation compared to control group supplemented with quercetin. The manifestation of the combination of quercetin supplementation with exercise was more evident in the pro-reverse cholesterol transport genes, indicating a plausible mechanism for their combined beneficial effect. The pathogenesis of atherosclerosis, the major cause of cardiovascular diseases (CVD), is multifactorial and therefore its treatment approaches and the ability to regress the plaque are complicated. Data from research on animal models and clinical studies have indicated that moderate daily exercise can alleviate the risk for the development of atherosclerotic plaques, while the same has not been true for the supplementation of antioxidants.
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spelling pubmed-40410422014-06-03 Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation Garelnabi, Mahdi Mahini, Halleh Wilson, Thomas J Int Soc Sports Nutr Research Article STUDY OBJECTIVES: We proposed that mice supplemented with quercetin, a class of flavonoids known to have antioxidant and anti-inflammatory properties, will have profound effects on the pathophysiology of atherosclerosis when combined with exercise. STUDY DESIGN: Forty C57BL6 LDLr −/− mice were divided into four groups (n = 10): control untreated (NN); control group supplemented with 100 μg/day of quercetin (NQ); exercise group (EN); and exercise group supplemented with 100 μg/day of quercetin (EQ). All animals were fed atherogenic diet. The exercise groups were run on a treadmill for 30 minutes, 15 m/min for 5 days/week for 30 days. After 30 day animals were sacrificed and tissues were harvested. RESULTS AND CONCLUSION: Mice supplemented with quercetin during exercise sessions had 78% atherosclerotic plaque reduction compared to control mice and 40% less atherosclerotic plaque formation compared to control group supplemented with quercetin. The manifestation of the combination of quercetin supplementation with exercise was more evident in the pro-reverse cholesterol transport genes, indicating a plausible mechanism for their combined beneficial effect. The pathogenesis of atherosclerosis, the major cause of cardiovascular diseases (CVD), is multifactorial and therefore its treatment approaches and the ability to regress the plaque are complicated. Data from research on animal models and clinical studies have indicated that moderate daily exercise can alleviate the risk for the development of atherosclerotic plaques, while the same has not been true for the supplementation of antioxidants. BioMed Central 2014-05-27 /pmc/articles/PMC4041042/ /pubmed/24890098 http://dx.doi.org/10.1186/1550-2783-11-22 Text en Copyright © 2014 Garelnabi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Garelnabi, Mahdi
Mahini, Halleh
Wilson, Thomas
Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
title Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
title_full Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
title_fullStr Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
title_full_unstemmed Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
title_short Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
title_sort quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041042/
https://www.ncbi.nlm.nih.gov/pubmed/24890098
http://dx.doi.org/10.1186/1550-2783-11-22
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