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Structural basis for the recognition of diastereomeric 5′,8-cyclo-2′-deoxypurine lesions by the human nucleotide excision repair system
The hydroxyl radical is a powerful oxidant that generates DNA lesions including the stereoisomeric R and S 5′,8-cyclo-2′-deoxyadenosine (cdA) and 5′,8-cyclo-2′-deoxyguanosine (cdG) pairs that have been detected in cellular DNA. Unlike some other oxidatively generated DNA lesions, cdG and cdA are rep...
Autores principales: | Kropachev, Konstantin, Ding, Shuang, Terzidis, Michael A., Masi, Annalisa, Liu, Zhi, Cai, Yuqin, Kolbanovskiy, Marina, Chatgilialoglu, Chryssostomos, Broyde, Suse, Geacintov, Nicholas E., Shafirovich, Vladimir |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041128/ https://www.ncbi.nlm.nih.gov/pubmed/24615810 http://dx.doi.org/10.1093/nar/gku162 |
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