Cargando…

The multiple facets of drug resistance: one history, different approaches

Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature presents studies in monolayer cell cultures, 3D cell cultures or in vivo studies, but rare...

Descripción completa

Detalles Bibliográficos
Autores principales: Niero, Evandro Luís, Rocha-Sales, Bianca, Lauand, Camila, Cortez, Beatriz Araujo, de Souza, Marcelo Medina, Rezende-Teixeira, Paula, Urabayashi, Marcel Shiniti, Martens, Adam Arai, Neves, Jorge Henrique, Machado-Santelli, Gláucia Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041145/
https://www.ncbi.nlm.nih.gov/pubmed/24775603
http://dx.doi.org/10.1186/1756-9966-33-37
_version_ 1782318638157529088
author Niero, Evandro Luís
Rocha-Sales, Bianca
Lauand, Camila
Cortez, Beatriz Araujo
de Souza, Marcelo Medina
Rezende-Teixeira, Paula
Urabayashi, Marcel Shiniti
Martens, Adam Arai
Neves, Jorge Henrique
Machado-Santelli, Gláucia Maria
author_facet Niero, Evandro Luís
Rocha-Sales, Bianca
Lauand, Camila
Cortez, Beatriz Araujo
de Souza, Marcelo Medina
Rezende-Teixeira, Paula
Urabayashi, Marcel Shiniti
Martens, Adam Arai
Neves, Jorge Henrique
Machado-Santelli, Gláucia Maria
author_sort Niero, Evandro Luís
collection PubMed
description Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature presents studies in monolayer cell cultures, 3D cell cultures or in vivo studies, but rarely the same work compares results of drug resistance in different models. Several of these works are presented in this review and show that usually cells in 3D culture are more resistant to drugs than monolayer cultured cells due to different mechanisms. Searching for new strategies to sensitize different tumors to chemotherapy, many methods have been studied to understand the mechanisms whereby cancer cells acquire drug resistance. These methods have been strongly advanced along the years and therapies using different drugs have been increasingly proposed to induce cell death in resistant cells of different cancers. Recently, cancer stem cells (CSCs) have been extensively studied because they would be the only cells capable of sustaining tumorigenesis. It is believed that the resistance of CSCs to currently used chemotherapeutics is a major contributing factor in cancer recurrence and later metastasis development. This review aims to appraise the experimental progress in the study of acquired drug resistance of cancer cells in different models as well as to understand the role of CSCs as the major contributing factor in cancer recurrence and metastasis development, describing how CSCs can be identified and isolated.
format Online
Article
Text
id pubmed-4041145
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-40411452014-06-03 The multiple facets of drug resistance: one history, different approaches Niero, Evandro Luís Rocha-Sales, Bianca Lauand, Camila Cortez, Beatriz Araujo de Souza, Marcelo Medina Rezende-Teixeira, Paula Urabayashi, Marcel Shiniti Martens, Adam Arai Neves, Jorge Henrique Machado-Santelli, Gláucia Maria J Exp Clin Cancer Res Review Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature presents studies in monolayer cell cultures, 3D cell cultures or in vivo studies, but rarely the same work compares results of drug resistance in different models. Several of these works are presented in this review and show that usually cells in 3D culture are more resistant to drugs than monolayer cultured cells due to different mechanisms. Searching for new strategies to sensitize different tumors to chemotherapy, many methods have been studied to understand the mechanisms whereby cancer cells acquire drug resistance. These methods have been strongly advanced along the years and therapies using different drugs have been increasingly proposed to induce cell death in resistant cells of different cancers. Recently, cancer stem cells (CSCs) have been extensively studied because they would be the only cells capable of sustaining tumorigenesis. It is believed that the resistance of CSCs to currently used chemotherapeutics is a major contributing factor in cancer recurrence and later metastasis development. This review aims to appraise the experimental progress in the study of acquired drug resistance of cancer cells in different models as well as to understand the role of CSCs as the major contributing factor in cancer recurrence and metastasis development, describing how CSCs can be identified and isolated. BioMed Central 2014-04-28 /pmc/articles/PMC4041145/ /pubmed/24775603 http://dx.doi.org/10.1186/1756-9966-33-37 Text en Copyright © 2014 Niero et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Niero, Evandro Luís
Rocha-Sales, Bianca
Lauand, Camila
Cortez, Beatriz Araujo
de Souza, Marcelo Medina
Rezende-Teixeira, Paula
Urabayashi, Marcel Shiniti
Martens, Adam Arai
Neves, Jorge Henrique
Machado-Santelli, Gláucia Maria
The multiple facets of drug resistance: one history, different approaches
title The multiple facets of drug resistance: one history, different approaches
title_full The multiple facets of drug resistance: one history, different approaches
title_fullStr The multiple facets of drug resistance: one history, different approaches
title_full_unstemmed The multiple facets of drug resistance: one history, different approaches
title_short The multiple facets of drug resistance: one history, different approaches
title_sort multiple facets of drug resistance: one history, different approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041145/
https://www.ncbi.nlm.nih.gov/pubmed/24775603
http://dx.doi.org/10.1186/1756-9966-33-37
work_keys_str_mv AT nieroevandroluis themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT rochasalesbianca themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT lauandcamila themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT cortezbeatrizaraujo themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT desouzamarcelomedina themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT rezendeteixeirapaula themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT urabayashimarcelshiniti themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT martensadamarai themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT nevesjorgehenrique themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT machadosantelliglauciamaria themultiplefacetsofdrugresistanceonehistorydifferentapproaches
AT nieroevandroluis multiplefacetsofdrugresistanceonehistorydifferentapproaches
AT rochasalesbianca multiplefacetsofdrugresistanceonehistorydifferentapproaches
AT lauandcamila multiplefacetsofdrugresistanceonehistorydifferentapproaches
AT cortezbeatrizaraujo multiplefacetsofdrugresistanceonehistorydifferentapproaches
AT desouzamarcelomedina multiplefacetsofdrugresistanceonehistorydifferentapproaches
AT rezendeteixeirapaula multiplefacetsofdrugresistanceonehistorydifferentapproaches
AT urabayashimarcelshiniti multiplefacetsofdrugresistanceonehistorydifferentapproaches
AT martensadamarai multiplefacetsofdrugresistanceonehistorydifferentapproaches
AT nevesjorgehenrique multiplefacetsofdrugresistanceonehistorydifferentapproaches
AT machadosantelliglauciamaria multiplefacetsofdrugresistanceonehistorydifferentapproaches