Cargando…
Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy
The health and performance of the gastrointestinal tract is influenced by the interaction of a variety of factors, including diet, nutritional status, genetics, environment, stress, the intestinal microbiota, immune status, and gut barrier. Disruptions in one or more of these factors can lead to ent...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041178/ https://www.ncbi.nlm.nih.gov/pubmed/24904221 http://dx.doi.org/10.2147/CEG.S62823 |
_version_ | 1782318640225320960 |
---|---|
author | Petschow, Bryon W Burnett, Bruce Shaw, Audrey L Weaver, Eric M Klein, Gerald L |
author_facet | Petschow, Bryon W Burnett, Bruce Shaw, Audrey L Weaver, Eric M Klein, Gerald L |
author_sort | Petschow, Bryon W |
collection | PubMed |
description | The health and performance of the gastrointestinal tract is influenced by the interaction of a variety of factors, including diet, nutritional status, genetics, environment, stress, the intestinal microbiota, immune status, and gut barrier. Disruptions in one or more of these factors can lead to enteropathy or intestinal disorders that are known to occur in concert with certain disease states or conditions such as irritable bowel syndrome or human immunodeficiency virus (HIV) infection. Nutritional support in the form of a medical food along with current therapies could help manage the adverse effects of enteropathy, which include effects on nutrient digestion, absorption, and metabolism, as well as utilization of nutrients from foodstuffs. Numerous studies have demonstrated that oral administration of plasma- or serum-derived protein concentrates containing high levels of immunoglobulins can improve weight management, normalize gut barrier function, and reduce the severity of enteropathy in animals. Recent trials in humans provide preliminary evidence that a serum-derived bovine immunoglobulin/protein isolate is safe and improves symptoms, nutritional status, and various biomarkers associated with enteropathy in patients with HIV infection or diarrhea-predominant irritable bowel syndrome. This review summarizes data from preclinical and clinical studies with immunoglobulin-containing plasma/serum protein concentrates, with a focus on the postulated mode of action of serum-derived bovine immunoglobulin/protein isolate for patients with enteropathy. |
format | Online Article Text |
id | pubmed-4041178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40411782014-06-05 Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy Petschow, Bryon W Burnett, Bruce Shaw, Audrey L Weaver, Eric M Klein, Gerald L Clin Exp Gastroenterol Review The health and performance of the gastrointestinal tract is influenced by the interaction of a variety of factors, including diet, nutritional status, genetics, environment, stress, the intestinal microbiota, immune status, and gut barrier. Disruptions in one or more of these factors can lead to enteropathy or intestinal disorders that are known to occur in concert with certain disease states or conditions such as irritable bowel syndrome or human immunodeficiency virus (HIV) infection. Nutritional support in the form of a medical food along with current therapies could help manage the adverse effects of enteropathy, which include effects on nutrient digestion, absorption, and metabolism, as well as utilization of nutrients from foodstuffs. Numerous studies have demonstrated that oral administration of plasma- or serum-derived protein concentrates containing high levels of immunoglobulins can improve weight management, normalize gut barrier function, and reduce the severity of enteropathy in animals. Recent trials in humans provide preliminary evidence that a serum-derived bovine immunoglobulin/protein isolate is safe and improves symptoms, nutritional status, and various biomarkers associated with enteropathy in patients with HIV infection or diarrhea-predominant irritable bowel syndrome. This review summarizes data from preclinical and clinical studies with immunoglobulin-containing plasma/serum protein concentrates, with a focus on the postulated mode of action of serum-derived bovine immunoglobulin/protein isolate for patients with enteropathy. Dove Medical Press 2014-05-24 /pmc/articles/PMC4041178/ /pubmed/24904221 http://dx.doi.org/10.2147/CEG.S62823 Text en © 2014 Petschow et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Petschow, Bryon W Burnett, Bruce Shaw, Audrey L Weaver, Eric M Klein, Gerald L Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy |
title | Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy |
title_full | Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy |
title_fullStr | Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy |
title_full_unstemmed | Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy |
title_short | Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy |
title_sort | serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041178/ https://www.ncbi.nlm.nih.gov/pubmed/24904221 http://dx.doi.org/10.2147/CEG.S62823 |
work_keys_str_mv | AT petschowbryonw serumderivedbovineimmunoglobulinproteinisolatepostulatedmechanismofactionformanagementofenteropathy AT burnettbruce serumderivedbovineimmunoglobulinproteinisolatepostulatedmechanismofactionformanagementofenteropathy AT shawaudreyl serumderivedbovineimmunoglobulinproteinisolatepostulatedmechanismofactionformanagementofenteropathy AT weaverericm serumderivedbovineimmunoglobulinproteinisolatepostulatedmechanismofactionformanagementofenteropathy AT kleingeraldl serumderivedbovineimmunoglobulinproteinisolatepostulatedmechanismofactionformanagementofenteropathy |