Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

Resection of DNA double-strand breaks (DSBs) is a pivotal step during which the choice between NHEJ and HR DNA repair pathways is made. While CDKs are known to control initiation of resection, their role in regulating long-range resection remains elusive. Here we show that CDKs 1/2 phosphorylate the...

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Detalles Bibliográficos
Autores principales: Tomimatsu, Nozomi, Mukherjee, Bipasha, Hardebeck, Molly Catherine, Ilcheva, Mariya, Camacho, Cristel Vanessa, Harris, Janelle Louise, Porteus, Matthew, Llorente, Bertrand, Khanna, Kum Kum, Burma, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041212/
https://www.ncbi.nlm.nih.gov/pubmed/24705021
http://dx.doi.org/10.1038/ncomms4561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041212/
https://www.ncbi.nlm.nih.gov/pubmed/24705021
http://dx.doi.org/10.1038/ncomms4561

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