cAMP Signaling Affects Irreversible Attachment During Biofilm Formation by Pseudomonas aeruginosa PAO1

Pseudomonas aeruginosa responds to environmental changes and regulates its life cycle from planktonic to biofilm modes of growth. The control of cell attachment to surfaces is one of the critical processes that determine this transition. Environmental signals are typically relayed to the cytoplasm b...

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Detalles Bibliográficos
Autores principales: Ono, Kaori, Oka, Rie, Toyofuku, Masanori, Sakaguchi, Ayane, Hamada, Masakaze, Yoshida, Shiomi, Nomura, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Microbial Ecology/The Japanese Society of Soil Microbiology 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041239/
https://www.ncbi.nlm.nih.gov/pubmed/24553108
http://dx.doi.org/10.1264/jsme2.ME13151
Descripción
Sumario:Pseudomonas aeruginosa responds to environmental changes and regulates its life cycle from planktonic to biofilm modes of growth. The control of cell attachment to surfaces is one of the critical processes that determine this transition. Environmental signals are typically relayed to the cytoplasm by second messenger systems. We here demonstrated that the second messenger, cAMP, regulated the attachment of cells. Our results suggest cAMP inhibited the transition from reversible to irreversible attachment. Further analyses revealed that cell surface hydrophobicity, one of the key factors in cell attachment, was altered by cAMP.

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