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Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs

RNA interference (RNAi) has become an important tool in functional genomics and has an intriguing therapeutic potential. However, the current design of short interfering RNAs (siRNAs) is not optimal for in vivo applications. Non-ionic phosphate backbone modifications may have the potential to improv...

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Detalles Bibliográficos
Autores principales:	Mutisya, Daniel, Selvam, Chelliah, Lunstad, Benjamin D., Pallan, Pradeep S., Haas, Amanda, Leake, Devin, Egli, Martin, Rozners, Eriks
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041415/ https://www.ncbi.nlm.nih.gov/pubmed/24813446 http://dx.doi.org/10.1093/nar/gku235

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