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Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation
Regulation of SMN2 exon 7 splicing is crucial for the production of active SMN protein and the survival of Spinal Muscular Atrophy (SMA) patients. One of the most efficient activators of exon 7 inclusion is hnRNP G, which is recruited to the exon by Tra2-β1. We report that in addition to the C-termi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041419/ https://www.ncbi.nlm.nih.gov/pubmed/24692659 http://dx.doi.org/10.1093/nar/gku244 |