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The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage

Mus81-Mms4/EME1 is a DNA structure-selective endonuclease that cleaves joint DNA molecules that form during homologous recombination in mitotic and meiotic cells. Here, we demonstrate by kinetic analysis using physically tethered DNA substrates that budding yeast Mus81-Mms4 requires inherent rotatio...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Sucheta, Wright, William Douglass, Ehmsen, Kirk Tevebaugh, Heyer, Wolf-Dietrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041439/ https://www.ncbi.nlm.nih.gov/pubmed/24744239 http://dx.doi.org/10.1093/nar/gku265

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