The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex

There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function across multiple cell types. Here, we show that FOXK2 binds to the SIN3A and...

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Autores principales: Ji, Zongling, Mohammed, Hisham, Webber, Aaron, Ridsdale, Jenna, Han, Namshik, Carroll, Jason S., Sharrocks, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041447/
https://www.ncbi.nlm.nih.gov/pubmed/24748658
http://dx.doi.org/10.1093/nar/gku274
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author Ji, Zongling
Mohammed, Hisham
Webber, Aaron
Ridsdale, Jenna
Han, Namshik
Carroll, Jason S.
Sharrocks, Andrew D.
author_facet Ji, Zongling
Mohammed, Hisham
Webber, Aaron
Ridsdale, Jenna
Han, Namshik
Carroll, Jason S.
Sharrocks, Andrew D.
author_sort Ji, Zongling
collection PubMed
description There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function across multiple cell types. Here, we show that FOXK2 binds to the SIN3A and PR-DUB complexes. The PR-DUB complex contains the important tumour suppressor protein, the deubiquitinase BAP1. FOXK2 recruits BAP1 to DNA, promotes local histone deubiquitination and causes changes in target gene activity. Our results therefore provide an important link between BAP1 and the transcription factor FOXK2 and demonstrate how BAP1 can be recruited to specific regulatory loci.
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spelling pubmed-40414472014-06-11 The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex Ji, Zongling Mohammed, Hisham Webber, Aaron Ridsdale, Jenna Han, Namshik Carroll, Jason S. Sharrocks, Andrew D. Nucleic Acids Res Gene regulation, Chromatin and Epigenetics There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function across multiple cell types. Here, we show that FOXK2 binds to the SIN3A and PR-DUB complexes. The PR-DUB complex contains the important tumour suppressor protein, the deubiquitinase BAP1. FOXK2 recruits BAP1 to DNA, promotes local histone deubiquitination and causes changes in target gene activity. Our results therefore provide an important link between BAP1 and the transcription factor FOXK2 and demonstrate how BAP1 can be recruited to specific regulatory loci. Oxford University Press 2014-06-01 2014-04-19 /pmc/articles/PMC4041447/ /pubmed/24748658 http://dx.doi.org/10.1093/nar/gku274 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Gene regulation, Chromatin and Epigenetics
Ji, Zongling
Mohammed, Hisham
Webber, Aaron
Ridsdale, Jenna
Han, Namshik
Carroll, Jason S.
Sharrocks, Andrew D.
The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex
title The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex
title_full The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex
title_fullStr The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex
title_full_unstemmed The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex
title_short The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex
title_sort forkhead transcription factor foxk2 acts as a chromatin targeting factor for the bap1-containing histone deubiquitinase complex
topic Gene regulation, Chromatin and Epigenetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041447/
https://www.ncbi.nlm.nih.gov/pubmed/24748658
http://dx.doi.org/10.1093/nar/gku274
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