Cargando…

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

Myotonic dystrophy type 1 (DM1) is a dominantly inherited neuromuscular disorder resulting from expression of RNA containing an expanded CUG repeat (CUG(exp)). The pathogenic RNA is retained in nuclear foci. Poly-(CUG) binding proteins in the Muscleblind-like (MBNL) family are sequestered in foci, c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoskins, Jason W., Ofori, Leslie O., Chen, Catherine Z., Kumar, Amit, Sobczak, Krzysztof, Nakamori, Masayuki, Southall, Noel, Patnaik, Samarjit, Marugan, Juan J., Zheng, Wei, Austin, Christopher P., Disney, Matthew D., Miller, Benjamin L., Thornton, Charles A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041448/ https://www.ncbi.nlm.nih.gov/pubmed/24799433 http://dx.doi.org/10.1093/nar/gku275

Ejemplares similares

Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript
por: Konieczny, Patryk, et al.
Publicado: (2017)

MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3
por: Gooding, Clare, et al.
Publicado: (2013)

Alternative splicing analysis in human monocytes and macrophages reveals MBNL1 as major regulator
por: Liu, Hongfei, et al.
Publicado: (2018)

A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts
por: Yamashita, Akira, et al.
Publicado: (2013)

Reinforcement of transcriptional silencing by a positive feedback between DNA methylation and non-coding transcription
por: Rothi, M Hafiz, et al.
Publicado: (2021)

An insulator element 3′ to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells
por: Blackledge, Neil P., et al.
Publicado: (2009)

Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs
por: Chikashige, Yuji, et al.
Publicado: (2020)

Promoter cross-talk via a shared enhancer explains paternally biased expression of Nctc1 at the Igf2/H19/Nctc1 imprinted locus
por: Eun, Bokkee, et al.
Publicado: (2013)

Genome-wide evidence for an essential role of the human Staf/ZNF143 transcription factor in bidirectional transcription
por: Anno, Yannick-Noël, et al.
Publicado: (2011)

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks
por: Hirotsu, Yosuke, et al.
Publicado: (2012)

The Igf2/H19 muscle enhancer is an active transcriptional complex
por: Eun, Bokkee, et al.
Publicado: (2013)

FRET studies of a landscape of Lac repressor-mediated DNA loops
por: Haeusler, Aaron R., et al.
Publicado: (2012)

Local states of chromatin compaction at transcription start sites control transcription levels
por: Ishihara, Satoru, et al.
Publicado: (2021)

Nucleosome occupancy reveals regulatory elements of the CFTR promoter
por: Ott, Christopher J., et al.
Publicado: (2012)

Promoter RNA links transcriptional regulation of inflammatory pathway genes
por: Matsui, Masayuki, et al.
Publicado: (2013)

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells
por: Akdemir, Kadir C., et al.
Publicado: (2014)

CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness
por: Pereira, Bruno, et al.
Publicado: (2013)

Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome
por: Arimura, Yasuhiro, et al.
Publicado: (2018)

Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity
por: Suzuki, Tomohiro, et al.
Publicado: (2023)

The transcription factor Sox5 modulates Sox10 function during melanocyte development
por: Stolt, C. Claus, et al.
Publicado: (2008)

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex
por: Thiaville, Michelle M., et al.
Publicado: (2008)

S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum
por: André, Gaëlle, et al.
Publicado: (2008)

The CaMV transactivator/viroplasmin interferes with RDR6-dependent trans-acting and secondary siRNA pathways in Arabidopsis
por: Shivaprasad, Padubidri V., et al.
Publicado: (2008)

Expanded binding specificity of the human histone chaperone NASP
por: Wang, Huanyu, et al.
Publicado: (2008)

Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRγ
por: Song, Guisheng, et al.
Publicado: (2008)

Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
por: Roque, Alicia, et al.
Publicado: (2008)

Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk
por: Spatuzza, Carmen, et al.
Publicado: (2008)

Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
por: Ray, Sutapa, et al.
Publicado: (2008)

TAp73β and DNp73β activate the expression of the pro-survival caspase-2(S)
por: Toh, Wen Hong, et al.
Publicado: (2008)

The orphan receptor ERRα interferes with steroid signaling
por: Teyssier, Catherine, et al.
Publicado: (2008)

An intronic microRNA silences genes that are functionally antagonistic to its host gene
por: Barik, Sailen
Publicado: (2008)

Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements
por: Taylor, Jennifer M., et al.
Publicado: (2008)

A high-throughput percentage-of-binding strategy to measure binding energies in DNA–protein interactions: application to genome-scale site discovery
por: Wang, Xiaohu, et al.
Publicado: (2008)

The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation
por: Stefanovsky, Victor Y., et al.
Publicado: (2008)

Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription
por: Wang, Wen-Ling, et al.
Publicado: (2008)

Context dependent function of APPb enhancer identified using enhancer trap-containing BACs as transgenes in zebrafish
por: Shakes, Leighcraft A., et al.
Publicado: (2008)

Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L
por: Jurkowska, Renata Z., et al.
Publicado: (2008)

Characterization of new regulatory elements within the Drosophila bithorax complex
por: Pérez-Lluch, Sílvia, et al.
Publicado: (2008)

Positional distribution of human transcription factor binding sites
por: Koudritsky, Mark, et al.
Publicado: (2008)

The 5′ end of two redundant sRNAs is involved in the regulation of multiple targets, including their own regulator
por: Guillier, Maude, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_u2671vn666rhtr98js2s34aakj