Evidence that TSC2 acts as a transcription factor and binds to and represses the promoter of Epiregulin

The TSC2 gene, mutated in patients with tuberous sclerosis complex (TSC), encodes a 200 kDa protein TSC2 (tuberin). The importance of TSC2 in the regulation of cell growth and proliferation is irrefutable. TSC2 in complex with TSC1 negatively regulates the mTOR complex 1 (mTORC1) via RHEB in the PI3...

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Detalles Bibliográficos
Autores principales: Pradhan, Shalmali Avinash, Rather, Mohammad Iqbal, Tiwari, Ankana, Bhat, Vishwanath Kumble, Kumar, Arun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041451/
https://www.ncbi.nlm.nih.gov/pubmed/24748662
http://dx.doi.org/10.1093/nar/gku278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041451/
https://www.ncbi.nlm.nih.gov/pubmed/24748662
http://dx.doi.org/10.1093/nar/gku278

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