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High Throughput Mutagenesis for Identification of Residues Regulating Human Prostacyclin (hIP) Receptor Expression and Function
The human prostacyclin receptor (hIP receptor) is a seven-transmembrane G protein-coupled receptor (GPCR) that plays a critical role in vascular smooth muscle relaxation and platelet aggregation. hIP receptor dysfunction has been implicated in numerous cardiovascular abnormalities, including myocard...
Autores principales: | Bill, Anke, Rosethorne, Elizabeth M., Kent, Toby C., Fawcett, Lindsay, Burchell, Lynn, van Diepen, Michiel T., Marelli, Anthony, Batalov, Sergey, Miraglia, Loren, Orth, Anthony P., Renaud, Nicole A., Charlton, Steven J., Gosling, Martin, Gaither, L. Alex, Groot-Kormelink, Paul J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041722/ https://www.ncbi.nlm.nih.gov/pubmed/24886841 http://dx.doi.org/10.1371/journal.pone.0097973 |
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