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Generation of Replication-Proficient Influenza Virus NS1 Point Mutants with Interferon-Hyperinducer Phenotype

The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN. Here we report an unbiased mutagenesis approach to identi...

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Detalles Bibliográficos
Autores principales:	Pérez-Cidoncha, Maite, Killip, Marian J., Asensio, Víctor J., Fernández, Yolanda, Bengoechea, José A., Randall, Richard E., Ortín, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041880/ https://www.ncbi.nlm.nih.gov/pubmed/24887174 http://dx.doi.org/10.1371/journal.pone.0098668

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