Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53

BACKGROUND: Survivin, a member of the inhibitor of apoptosis (IAP) gene family, has a dual role in mitosis and in apoptosis. It is abundantly expressed in every human tumor, compared with normal tissues. During mitosis Survivin assembles with the chromosomal passenger complex and regulates chromosom...

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Detalles Bibliográficos
Autores principales: Wiedemuth, Ralf, Klink, Barbara, Töpfer, Katrin, Schröck, Evelin, Schackert, Gabriele, Tatsuka, Masaaki, Temme, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041913/
https://www.ncbi.nlm.nih.gov/pubmed/24886358
http://dx.doi.org/10.1186/1476-4598-13-107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041913/
https://www.ncbi.nlm.nih.gov/pubmed/24886358
http://dx.doi.org/10.1186/1476-4598-13-107

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