Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?

BACKGROUND: Activating epidermal growth factor receptor (EGFR) mutations characterize a subgroup of non-small-cell lung cancer that benefit from first line EGFR tyrosine kinase inhibitors (EGFR-TKI). However, the existence of polyclonal cell populations may hinder personalized-medicine strategies as...

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Detalles Bibliográficos
Autores principales: Mansuet-Lupo, Audrey, Zouiti, Fouzia, Alifano, Marco, Tallet, Anne, Charpentier, Marie-Christine, Ducruit, Véronique, Devez, Fabrice, Lemaitre, Fanny, Laurent-Puig, Pierre, Damotte, Diane, Blons, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041917/
https://www.ncbi.nlm.nih.gov/pubmed/24885034
http://dx.doi.org/10.1186/1479-5876-12-131

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