Treatment options for patients with large cell neuroendocrine carcinoma of the lung

Large cell neuroendocrine carcinoma (LCNEC) of the lung is categorized as a variant of large cell carcinomas, and LCNEC tumors display biological behaviors resembling those of small cell lung carcinomas and features of high-grade neuroendocrine tumors. Because patients with LCNEC have a poor prognos...

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Detalles Bibliográficos
Autores principales: Iyoda, Akira, Makino, Takashi, Koezuka, Satoshi, Otsuka, Hajime, Hata, Yoshinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2014
Materias:
Current Topics Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042022/
https://www.ncbi.nlm.nih.gov/pubmed/24719260
http://dx.doi.org/10.1007/s11748-014-0379-9
Descripción
Sumario:Large cell neuroendocrine carcinoma (LCNEC) of the lung is categorized as a variant of large cell carcinomas, and LCNEC tumors display biological behaviors resembling those of small cell lung carcinomas and features of high-grade neuroendocrine tumors. Because patients with LCNEC have a poor prognosis, surgery alone is not sufficient. Multimodality therapies, including adjuvant chemotherapy, appear promising for improved prognosis in patients with LCNEC. In this review article, we discuss treatment options for patients with LCNEC of the lung.

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