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Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort

The non-linear inverse relationship between RR-intervals and heart rate (HR) contributes significantly to the heart rate variability (HRV) parameters and their performance in mortality prediction. To determine the level of influence HR exerts over HRV parameters' prognostic power, we studied th...

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Autores principales: Pradhapan, Paruthi, Tarvainen, Mika P., Nieminen, Tuomo, Lehtinen, Rami, Nikus, Kjell, Lehtimäki, Terho, Kähönen, Mika, Viik, Jari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042064/
https://www.ncbi.nlm.nih.gov/pubmed/24917825
http://dx.doi.org/10.3389/fphys.2014.00208
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author Pradhapan, Paruthi
Tarvainen, Mika P.
Nieminen, Tuomo
Lehtinen, Rami
Nikus, Kjell
Lehtimäki, Terho
Kähönen, Mika
Viik, Jari
author_facet Pradhapan, Paruthi
Tarvainen, Mika P.
Nieminen, Tuomo
Lehtinen, Rami
Nikus, Kjell
Lehtimäki, Terho
Kähönen, Mika
Viik, Jari
author_sort Pradhapan, Paruthi
collection PubMed
description The non-linear inverse relationship between RR-intervals and heart rate (HR) contributes significantly to the heart rate variability (HRV) parameters and their performance in mortality prediction. To determine the level of influence HR exerts over HRV parameters' prognostic power, we studied the predictive performance for different HR levels by applying eight correction procedures, multiplying or dividing HRV parameters by the mean RR-interval (RR(avg)) to the power 0.5–16. Data collected from 1288 patients in The Finnish Cardiovascular Study (FINCAVAS), who satisfied the inclusion criteria, was used for the analyses. HRV parameters (RMSSD, VLF Power and LF Power) were calculated from 2-min segment in the rest phase before exercise and 2-min recovery period immediately after peak exercise. Area under the receiver operating characteristic curve (AUC) was used to determine the predictive performance for each parameter with and without HR corrections in rest and recovery phases. The division of HRV parameters by segment's RR(avg) to the power 2 (HRV(DIV-2)) showed the highest predictive performance under the rest phase (RMSSD: 0.67/0.66; VLF Power: 0.70/0.62; LF Power: 0.79/0.65; cardiac mortality/non-cardiac mortality) with minimum correlation to HR (r = −0.15 to 0.15). In the recovery phase, Kaplan-Meier (KM) survival analysis revealed good risk stratification capacity at HRV(DIV-2) in both groups (cardiac and non-cardiac mortality). Although higher powers of correction (HRV(DIV-4)and HRV(DIV-8)) improved predictive performance during recovery, they induced an increased positive correlation to HR. Thus, we inferred that predictive capacity of HRV during rest and recovery is augmented when its dependence on HR is weakened by applying appropriate correction procedures.
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spelling pubmed-40420642014-06-10 Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort Pradhapan, Paruthi Tarvainen, Mika P. Nieminen, Tuomo Lehtinen, Rami Nikus, Kjell Lehtimäki, Terho Kähönen, Mika Viik, Jari Front Physiol Physiology The non-linear inverse relationship between RR-intervals and heart rate (HR) contributes significantly to the heart rate variability (HRV) parameters and their performance in mortality prediction. To determine the level of influence HR exerts over HRV parameters' prognostic power, we studied the predictive performance for different HR levels by applying eight correction procedures, multiplying or dividing HRV parameters by the mean RR-interval (RR(avg)) to the power 0.5–16. Data collected from 1288 patients in The Finnish Cardiovascular Study (FINCAVAS), who satisfied the inclusion criteria, was used for the analyses. HRV parameters (RMSSD, VLF Power and LF Power) were calculated from 2-min segment in the rest phase before exercise and 2-min recovery period immediately after peak exercise. Area under the receiver operating characteristic curve (AUC) was used to determine the predictive performance for each parameter with and without HR corrections in rest and recovery phases. The division of HRV parameters by segment's RR(avg) to the power 2 (HRV(DIV-2)) showed the highest predictive performance under the rest phase (RMSSD: 0.67/0.66; VLF Power: 0.70/0.62; LF Power: 0.79/0.65; cardiac mortality/non-cardiac mortality) with minimum correlation to HR (r = −0.15 to 0.15). In the recovery phase, Kaplan-Meier (KM) survival analysis revealed good risk stratification capacity at HRV(DIV-2) in both groups (cardiac and non-cardiac mortality). Although higher powers of correction (HRV(DIV-4)and HRV(DIV-8)) improved predictive performance during recovery, they induced an increased positive correlation to HR. Thus, we inferred that predictive capacity of HRV during rest and recovery is augmented when its dependence on HR is weakened by applying appropriate correction procedures. Frontiers Media S.A. 2014-06-03 /pmc/articles/PMC4042064/ /pubmed/24917825 http://dx.doi.org/10.3389/fphys.2014.00208 Text en Copyright © 2014 Pradhapan, Tarvainen, Nieminen, Lehtinen, Nikus, Lehtimäki, Kähönen and Viik. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Pradhapan, Paruthi
Tarvainen, Mika P.
Nieminen, Tuomo
Lehtinen, Rami
Nikus, Kjell
Lehtimäki, Terho
Kähönen, Mika
Viik, Jari
Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort
title Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort
title_full Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort
title_fullStr Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort
title_full_unstemmed Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort
title_short Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort
title_sort effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the fincavas cohort
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042064/
https://www.ncbi.nlm.nih.gov/pubmed/24917825
http://dx.doi.org/10.3389/fphys.2014.00208
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