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The de novo sequence origin of two long non-coding genes from an inter-genic region

BACKGROUND: The gene Polymorphic derived intron-containing, known as Pldi, is a long non-coding RNA (lncRNA) first discovered in mouse. Although parts of its sequence were reported to be conserved in rat and human, it can only be expressed in mouse testis with a mouse-specific transcription start si...

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Autores principales: Dai, Yulin, Li, Shengdi, Dong, Xiao, Sun, Han, Li, Chao, Liu, Zhi, Ying, Beili, Ding, Guohui, Li, Yixue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042238/
https://www.ncbi.nlm.nih.gov/pubmed/24564579
http://dx.doi.org/10.1186/1471-2164-14-S8-S6
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author Dai, Yulin
Li, Shengdi
Dong, Xiao
Sun, Han
Li, Chao
Liu, Zhi
Ying, Beili
Ding, Guohui
Li, Yixue
author_facet Dai, Yulin
Li, Shengdi
Dong, Xiao
Sun, Han
Li, Chao
Liu, Zhi
Ying, Beili
Ding, Guohui
Li, Yixue
author_sort Dai, Yulin
collection PubMed
description BACKGROUND: The gene Polymorphic derived intron-containing, known as Pldi, is a long non-coding RNA (lncRNA) first discovered in mouse. Although parts of its sequence were reported to be conserved in rat and human, it can only be expressed in mouse testis with a mouse-specific transcription start site. The consensus sequence of Pldi is also part of an antisense transcript AK158810 expressed in a wide range of mouse tissues. RESULT: We focused on sequence origin of Pldi and Ak158810. We demonstrated that their sequence was originated from an inter-genic region and is only presented in mammalians. Transposable events and chromosome rearrangements were involved in the evolution of ancestral sequence. Moreover, we discovered high conservation in part of this region was correlated with chromosome rearrangements, CpG demethylation and transcriptional factor binding motif. These results demonstrated that multiple factors contributed to the sequence origin of Pldi. CONCLUSIONS: We comprehensively analyzed the sequence origin of Pldi-Ak158810 loci. We provided various factors, including rearrangement, transposable elements, contributed to the formation of the sequence.
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spelling pubmed-40422382014-06-04 The de novo sequence origin of two long non-coding genes from an inter-genic region Dai, Yulin Li, Shengdi Dong, Xiao Sun, Han Li, Chao Liu, Zhi Ying, Beili Ding, Guohui Li, Yixue BMC Genomics Research BACKGROUND: The gene Polymorphic derived intron-containing, known as Pldi, is a long non-coding RNA (lncRNA) first discovered in mouse. Although parts of its sequence were reported to be conserved in rat and human, it can only be expressed in mouse testis with a mouse-specific transcription start site. The consensus sequence of Pldi is also part of an antisense transcript AK158810 expressed in a wide range of mouse tissues. RESULT: We focused on sequence origin of Pldi and Ak158810. We demonstrated that their sequence was originated from an inter-genic region and is only presented in mammalians. Transposable events and chromosome rearrangements were involved in the evolution of ancestral sequence. Moreover, we discovered high conservation in part of this region was correlated with chromosome rearrangements, CpG demethylation and transcriptional factor binding motif. These results demonstrated that multiple factors contributed to the sequence origin of Pldi. CONCLUSIONS: We comprehensively analyzed the sequence origin of Pldi-Ak158810 loci. We provided various factors, including rearrangement, transposable elements, contributed to the formation of the sequence. BioMed Central 2013-12-09 /pmc/articles/PMC4042238/ /pubmed/24564579 http://dx.doi.org/10.1186/1471-2164-14-S8-S6 Text en Copyright © 2013 Dai et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Dai, Yulin
Li, Shengdi
Dong, Xiao
Sun, Han
Li, Chao
Liu, Zhi
Ying, Beili
Ding, Guohui
Li, Yixue
The de novo sequence origin of two long non-coding genes from an inter-genic region
title The de novo sequence origin of two long non-coding genes from an inter-genic region
title_full The de novo sequence origin of two long non-coding genes from an inter-genic region
title_fullStr The de novo sequence origin of two long non-coding genes from an inter-genic region
title_full_unstemmed The de novo sequence origin of two long non-coding genes from an inter-genic region
title_short The de novo sequence origin of two long non-coding genes from an inter-genic region
title_sort de novo sequence origin of two long non-coding genes from an inter-genic region
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042238/
https://www.ncbi.nlm.nih.gov/pubmed/24564579
http://dx.doi.org/10.1186/1471-2164-14-S8-S6
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