Copy-neutral loss of heterozygosity is prevalent and a late event in the pathogenesis of FLT3/ITD AML

Patients with high FLT3 internal tandem duplication allelic ratios (FLT3/ITD-ARs) have a poor prognosis. Single-nucleotide polymorphism/comparative genomic hybridization, single-cell PCR and colony-forming assays were used to evaluate genotypic evolution of high FLT3/ITD-ARs in 85 acute myeloid leuk...

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Detalles Bibliográficos
Autores principales: Stirewalt, D L, Pogosova-Agadjanyan, E L, Tsuchiya, K, Joaquin, J, Meshinchi, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042297/
https://www.ncbi.nlm.nih.gov/pubmed/24786392
http://dx.doi.org/10.1038/bcj.2014.27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042297/
https://www.ncbi.nlm.nih.gov/pubmed/24786392
http://dx.doi.org/10.1038/bcj.2014.27

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