Induced pluripotent stem cells in hematology: current and future applications

Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell tec...

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Detalles Bibliográficos
Autores principales: Focosi, D, Amabile, G, Di Ruscio, A, Quaranta, P, Tenen, D G, Pistello, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042300/
https://www.ncbi.nlm.nih.gov/pubmed/24813079
http://dx.doi.org/10.1038/bcj.2014.30
Descripción
Sumario:Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation.

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