Induced pluripotent stem cells in hematology: current and future applications

Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell tec...

Descripción completa

Detalles Bibliográficos
Autores principales: Focosi, D, Amabile, G, Di Ruscio, A, Quaranta, P, Tenen, D G, Pistello, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042300/
https://www.ncbi.nlm.nih.gov/pubmed/24813079
http://dx.doi.org/10.1038/bcj.2014.30
_version_ 1782318790725337088
author Focosi, D
Amabile, G
Di Ruscio, A
Quaranta, P
Tenen, D G
Pistello, M
author_facet Focosi, D
Amabile, G
Di Ruscio, A
Quaranta, P
Tenen, D G
Pistello, M
author_sort Focosi, D
collection PubMed
description Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation.
format Online
Article
Text
id pubmed-4042300
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-40423002014-06-12 Induced pluripotent stem cells in hematology: current and future applications Focosi, D Amabile, G Di Ruscio, A Quaranta, P Tenen, D G Pistello, M Blood Cancer J Review Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation. Nature Publishing Group 2014-05 2014-05-09 /pmc/articles/PMC4042300/ /pubmed/24813079 http://dx.doi.org/10.1038/bcj.2014.30 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Review
Focosi, D
Amabile, G
Di Ruscio, A
Quaranta, P
Tenen, D G
Pistello, M
Induced pluripotent stem cells in hematology: current and future applications
title Induced pluripotent stem cells in hematology: current and future applications
title_full Induced pluripotent stem cells in hematology: current and future applications
title_fullStr Induced pluripotent stem cells in hematology: current and future applications
title_full_unstemmed Induced pluripotent stem cells in hematology: current and future applications
title_short Induced pluripotent stem cells in hematology: current and future applications
title_sort induced pluripotent stem cells in hematology: current and future applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042300/
https://www.ncbi.nlm.nih.gov/pubmed/24813079
http://dx.doi.org/10.1038/bcj.2014.30
work_keys_str_mv AT focosid inducedpluripotentstemcellsinhematologycurrentandfutureapplications
AT amabileg inducedpluripotentstemcellsinhematologycurrentandfutureapplications
AT diruscioa inducedpluripotentstemcellsinhematologycurrentandfutureapplications
AT quarantap inducedpluripotentstemcellsinhematologycurrentandfutureapplications
AT tenendg inducedpluripotentstemcellsinhematologycurrentandfutureapplications
AT pistellom inducedpluripotentstemcellsinhematologycurrentandfutureapplications

Ejemplares similares