Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity

B cells utilize three DNA alteration strategies—V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)—to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of t...

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Detalles Bibliográficos
Autores principales: Sun, Jianbo, Rothschild, Gerson, Pefanis, Evangelos, Basu, Uttiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042586/
https://www.ncbi.nlm.nih.gov/pubmed/23584095
http://dx.doi.org/10.4161/trns.24556
Descripción
Sumario:B cells utilize three DNA alteration strategies—V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)—to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of these three events, the single-strand DNA cytidine deaminase, Activation Induced cytidine Deaminase (AID), is responsible for SHM and CSR. Recent advances, discussed in this review article, point toward various components of RNA polymerase II “stalling” machinery as regulators of AID activity during antibody diversification and maintenance of B cell genome integrity.

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