Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity

B cells utilize three DNA alteration strategies—V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)—to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Jianbo, Rothschild, Gerson, Pefanis, Evangelos, Basu, Uttiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042586/
https://www.ncbi.nlm.nih.gov/pubmed/23584095
http://dx.doi.org/10.4161/trns.24556
_version_ 1782318837436252160
author Sun, Jianbo
Rothschild, Gerson
Pefanis, Evangelos
Basu, Uttiya
author_facet Sun, Jianbo
Rothschild, Gerson
Pefanis, Evangelos
Basu, Uttiya
author_sort Sun, Jianbo
collection PubMed
description B cells utilize three DNA alteration strategies—V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)—to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of these three events, the single-strand DNA cytidine deaminase, Activation Induced cytidine Deaminase (AID), is responsible for SHM and CSR. Recent advances, discussed in this review article, point toward various components of RNA polymerase II “stalling” machinery as regulators of AID activity during antibody diversification and maintenance of B cell genome integrity.
format Online
Article
Text
id pubmed-4042586
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-40425862014-06-04 Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity Sun, Jianbo Rothschild, Gerson Pefanis, Evangelos Basu, Uttiya Transcription Review B cells utilize three DNA alteration strategies—V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)—to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of these three events, the single-strand DNA cytidine deaminase, Activation Induced cytidine Deaminase (AID), is responsible for SHM and CSR. Recent advances, discussed in this review article, point toward various components of RNA polymerase II “stalling” machinery as regulators of AID activity during antibody diversification and maintenance of B cell genome integrity. Landes Bioscience 2013-05-01 2013-04-12 /pmc/articles/PMC4042586/ /pubmed/23584095 http://dx.doi.org/10.4161/trns.24556 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Sun, Jianbo
Rothschild, Gerson
Pefanis, Evangelos
Basu, Uttiya
Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity
title Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity
title_full Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity
title_fullStr Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity
title_full_unstemmed Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity
title_short Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity
title_sort transcriptional stalling in b-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042586/
https://www.ncbi.nlm.nih.gov/pubmed/23584095
http://dx.doi.org/10.4161/trns.24556
work_keys_str_mv AT sunjianbo transcriptionalstallinginblymphocytesamechanismforantibodydiversificationandmaintenanceofgenomicintegrity
AT rothschildgerson transcriptionalstallinginblymphocytesamechanismforantibodydiversificationandmaintenanceofgenomicintegrity
AT pefanisevangelos transcriptionalstallinginblymphocytesamechanismforantibodydiversificationandmaintenanceofgenomicintegrity
AT basuuttiya transcriptionalstallinginblymphocytesamechanismforantibodydiversificationandmaintenanceofgenomicintegrity

Ejemplares similares