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Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity
B cells utilize three DNA alteration strategies—V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)—to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042586/ https://www.ncbi.nlm.nih.gov/pubmed/23584095 http://dx.doi.org/10.4161/trns.24556 |