The great repression: Chromatin and cryptic transcription

The eukaryotic chromatin structure is essential in correctly defining transcription units. Impairing this structure can activate cryptic promoters, and lead to the accumulation of aberrant RNA transcripts. Here we discuss critical pathways that are responsible for the repression of cryptic transcrip...

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Detalles Bibliográficos
Autores principales: Hennig, Bianca P., Fischer, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042591/
https://www.ncbi.nlm.nih.gov/pubmed/23665541
http://dx.doi.org/10.4161/trns.24884
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author Hennig, Bianca P.
Fischer, Tamás
author_facet Hennig, Bianca P.
Fischer, Tamás
author_sort Hennig, Bianca P.
collection PubMed
description The eukaryotic chromatin structure is essential in correctly defining transcription units. Impairing this structure can activate cryptic promoters, and lead to the accumulation of aberrant RNA transcripts. Here we discuss critical pathways that are responsible for the repression of cryptic transcription and the maintenance of genome integrity.
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spelling pubmed-40425912014-06-04 The great repression: Chromatin and cryptic transcription Hennig, Bianca P. Fischer, Tamás Transcription Point of View The eukaryotic chromatin structure is essential in correctly defining transcription units. Impairing this structure can activate cryptic promoters, and lead to the accumulation of aberrant RNA transcripts. Here we discuss critical pathways that are responsible for the repression of cryptic transcription and the maintenance of genome integrity. Landes Bioscience 2013-05-01 2013-05-01 /pmc/articles/PMC4042591/ /pubmed/23665541 http://dx.doi.org/10.4161/trns.24884 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Point of View
Hennig, Bianca P.
Fischer, Tamás
The great repression: Chromatin and cryptic transcription
title The great repression: Chromatin and cryptic transcription
title_full The great repression: Chromatin and cryptic transcription
title_fullStr The great repression: Chromatin and cryptic transcription
title_full_unstemmed The great repression: Chromatin and cryptic transcription
title_short The great repression: Chromatin and cryptic transcription
title_sort great repression: chromatin and cryptic transcription
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042591/
https://www.ncbi.nlm.nih.gov/pubmed/23665541
http://dx.doi.org/10.4161/trns.24884
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