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Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells

Fanconi anemia is a rare genetic disorder that can lead to bone marrow failure, congenital abnormalities, and increased risk for leukemia and cancer. Cells with loss-of-function mutations in the FANC pathway are characterized by chromosome fragility, altered mutability, and abnormal regulation of th...

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Detalles Bibliográficos
Autores principales:	Nguyen, Thuy Vy, Riou, Lydia, Aoufouchi, Saïd, Rosselli, Filippo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042646/ https://www.ncbi.nlm.nih.gov/pubmed/24799500 http://dx.doi.org/10.1084/jem.20131637

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