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RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis

Rheumatoid arthritis (RA) significantly affects quality of life. We recently cloned synoviolin, a RING-type E3 ubiquitin ligase implicated in the endoplasmic reticulum-associated degradation (ERAD) pathway. Synoviolin is highly expressed in rheumatoid synovial cells and may be involved in the pathog...

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Detalles Bibliográficos
Autores principales:	YAGISHITA, NAOKO, ARATANI, SATOKO, LEACH, CRAIG, AMANO, TETSUYA, YAMANO, YOSHIHISA, NAKATANI, KO, NISHIOKA, KUSUKI, NAKAJIMA, TOSHIHIRO
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042867/ https://www.ncbi.nlm.nih.gov/pubmed/22992760 http://dx.doi.org/10.3892/ijmm.2012.1129

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