Cargando…

Therapeutic Effects of “Ibuprofen, Diphenhydramine and Aluminium MgS” on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial

OBJECTIVE: Recurrent aphthous stomatitis (RAS) is the most common and painful oral inflammatory lesion with an unknown etiology. This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain. M...

Descripción completa

Detalles Bibliográficos
Autores principales: Borhan-Mojabi, Katayoun, Mirmiran, Faezeh, Nassiri-Asl, Marjan, Nazeman, Pantea, Jahanihashemi, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043548/
https://www.ncbi.nlm.nih.gov/pubmed/24910692
_version_ 1782318926985691136
author Borhan-Mojabi, Katayoun
Mirmiran, Faezeh
Nassiri-Asl, Marjan
Nazeman, Pantea
Jahanihashemi, Hassan
author_facet Borhan-Mojabi, Katayoun
Mirmiran, Faezeh
Nassiri-Asl, Marjan
Nazeman, Pantea
Jahanihashemi, Hassan
author_sort Borhan-Mojabi, Katayoun
collection PubMed
description OBJECTIVE: Recurrent aphthous stomatitis (RAS) is the most common and painful oral inflammatory lesion with an unknown etiology. This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain. MATERIALS AND METHODS: Thirty-one patients with RAS participated in this double-blind clinical trial. Subjects were randomly divided into two groups. The control group (n=14) received drug mixture as drug A (diphenhydramine and AlMgS) and the case group (n=17) received drug B (ibuprofen, diphenhydramine and AlMgS). Drugs were topically applied on ulcers by the patients three times a day for 3 days. Patients were re-examined for the symptoms on the fourth day following their first visits using VAS (Visual Analogue Scale) tool. Statistical analysis was performed using paired t-test, independent t-test and chi-square test. RESULTS: The mean of pain reduction was 3.17±2 (P<0.001) and 3.82±1.79 (P<0.001) in the case and control group, respectively. The difference in pain reduction between both groups was not statistically significant. In addition, no significant difference was detected between the two groups regarding the duration of pain or burning sensation (P=0.57). CONCLUSION: The results of this study demonstrate that in comparison with diphenhydramine and AlMgS syrup, the studied mixture did not effectively reduce the level of pain, duration and burning sensation.
format Online
Article
Text
id pubmed-4043548
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Tehran University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-40435482014-06-06 Therapeutic Effects of “Ibuprofen, Diphenhydramine and Aluminium MgS” on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial Borhan-Mojabi, Katayoun Mirmiran, Faezeh Nassiri-Asl, Marjan Nazeman, Pantea Jahanihashemi, Hassan J Dent (Tehran) Original Article OBJECTIVE: Recurrent aphthous stomatitis (RAS) is the most common and painful oral inflammatory lesion with an unknown etiology. This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain. MATERIALS AND METHODS: Thirty-one patients with RAS participated in this double-blind clinical trial. Subjects were randomly divided into two groups. The control group (n=14) received drug mixture as drug A (diphenhydramine and AlMgS) and the case group (n=17) received drug B (ibuprofen, diphenhydramine and AlMgS). Drugs were topically applied on ulcers by the patients three times a day for 3 days. Patients were re-examined for the symptoms on the fourth day following their first visits using VAS (Visual Analogue Scale) tool. Statistical analysis was performed using paired t-test, independent t-test and chi-square test. RESULTS: The mean of pain reduction was 3.17±2 (P<0.001) and 3.82±1.79 (P<0.001) in the case and control group, respectively. The difference in pain reduction between both groups was not statistically significant. In addition, no significant difference was detected between the two groups regarding the duration of pain or burning sensation (P=0.57). CONCLUSION: The results of this study demonstrate that in comparison with diphenhydramine and AlMgS syrup, the studied mixture did not effectively reduce the level of pain, duration and burning sensation. Tehran University of Medical Sciences 2014-03 2014-03-31 /pmc/articles/PMC4043548/ /pubmed/24910692 Text en Copyright © Dental Research Center, Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Borhan-Mojabi, Katayoun
Mirmiran, Faezeh
Nassiri-Asl, Marjan
Nazeman, Pantea
Jahanihashemi, Hassan
Therapeutic Effects of “Ibuprofen, Diphenhydramine and Aluminium MgS” on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial
title Therapeutic Effects of “Ibuprofen, Diphenhydramine and Aluminium MgS” on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial
title_full Therapeutic Effects of “Ibuprofen, Diphenhydramine and Aluminium MgS” on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial
title_fullStr Therapeutic Effects of “Ibuprofen, Diphenhydramine and Aluminium MgS” on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial
title_full_unstemmed Therapeutic Effects of “Ibuprofen, Diphenhydramine and Aluminium MgS” on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial
title_short Therapeutic Effects of “Ibuprofen, Diphenhydramine and Aluminium MgS” on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial
title_sort therapeutic effects of “ibuprofen, diphenhydramine and aluminium mgs” on recurrent aphthous stomatitis: a randomized controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043548/
https://www.ncbi.nlm.nih.gov/pubmed/24910692
work_keys_str_mv AT borhanmojabikatayoun therapeuticeffectsofibuprofendiphenhydramineandaluminiummgsonrecurrentaphthousstomatitisarandomizedcontrolledtrial
AT mirmiranfaezeh therapeuticeffectsofibuprofendiphenhydramineandaluminiummgsonrecurrentaphthousstomatitisarandomizedcontrolledtrial
AT nassiriaslmarjan therapeuticeffectsofibuprofendiphenhydramineandaluminiummgsonrecurrentaphthousstomatitisarandomizedcontrolledtrial
AT nazemanpantea therapeuticeffectsofibuprofendiphenhydramineandaluminiummgsonrecurrentaphthousstomatitisarandomizedcontrolledtrial
AT jahanihashemihassan therapeuticeffectsofibuprofendiphenhydramineandaluminiummgsonrecurrentaphthousstomatitisarandomizedcontrolledtrial