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Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury

The aim of the present study was to investigate the effects of ulinastatin on cerebral oxygen metabolism and C-reactive protein (CRP) levels in patients with severe traumatic brain injury (sTBI). A total of 92 patients with sTBI, admitted to the First Affiliated Hospital of Xinxiang Medical Universi...

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Autores principales: HUI, LEI, SHEN, FAZHENG, CHANG, HAIGANG, LI, XIANGSHENG, GAO, GUOJUN, MA, JIWEI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043583/
https://www.ncbi.nlm.nih.gov/pubmed/24926366
http://dx.doi.org/10.3892/etm.2014.1666
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author HUI, LEI
SHEN, FAZHENG
CHANG, HAIGANG
LI, XIANGSHENG
GAO, GUOJUN
MA, JIWEI
author_facet HUI, LEI
SHEN, FAZHENG
CHANG, HAIGANG
LI, XIANGSHENG
GAO, GUOJUN
MA, JIWEI
author_sort HUI, LEI
collection PubMed
description The aim of the present study was to investigate the effects of ulinastatin on cerebral oxygen metabolism and C-reactive protein (CRP) levels in patients with severe traumatic brain injury (sTBI). A total of 92 patients with sTBI, admitted to the First Affiliated Hospital of Xinxiang Medical University (Xinxiang, China), were randomly divided into control and observation groups. The control group received conventional therapy plus a placebo (0.9% sodium chloride), while the observation group were administered conventional therapy plus 200,000 units ulinastatin via intravenous injection twice a day for seven days. Arterial and jugular venous blood was collected for blood gas analysis. The jugular venous blood lactate (JVBL), jugular venous bulb oxygen saturation (SjvO(2)), arteriovenous oxygen content difference (AVDO(2)) and cerebral extraction of oxygen (CEO(2)) levels were measured on day 1, 3, 5 and 7, as well as the level of CRP in the peripheral blood. In the control group, the level of JVBL decreased as compared with the level at day 1, however, no statistically significant differences were observed (P>0.05). By contrast, the observation group exhibited a significant reduction in the level of JVBL (P<0.05), which was also significantly lower compared with the control group (P<0.05). Statistically significant differences were observed between the two groups with regard to SjvO(2), AVDO(2) and CEO(2) on day 3, 5 and 7. The CRP levels in the two groups increased and peaked on day 3. However, the CRP level in the observation group significantly decreased on day 5 (35.27±15.18 mg/l) and day 7 (22.65±10.48 mg/l), which was lower compared with the control group (56.19±13.24 mg/l and 47.36±15.73 mg/l, respectively); statistically significant differences were observed (P<0.05). Therefore, ulinastatin effectively improved cerebral oxygen metabolism and reduced the CRP level in patients with sTBI.
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spelling pubmed-40435832014-06-12 Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury HUI, LEI SHEN, FAZHENG CHANG, HAIGANG LI, XIANGSHENG GAO, GUOJUN MA, JIWEI Exp Ther Med Articles The aim of the present study was to investigate the effects of ulinastatin on cerebral oxygen metabolism and C-reactive protein (CRP) levels in patients with severe traumatic brain injury (sTBI). A total of 92 patients with sTBI, admitted to the First Affiliated Hospital of Xinxiang Medical University (Xinxiang, China), were randomly divided into control and observation groups. The control group received conventional therapy plus a placebo (0.9% sodium chloride), while the observation group were administered conventional therapy plus 200,000 units ulinastatin via intravenous injection twice a day for seven days. Arterial and jugular venous blood was collected for blood gas analysis. The jugular venous blood lactate (JVBL), jugular venous bulb oxygen saturation (SjvO(2)), arteriovenous oxygen content difference (AVDO(2)) and cerebral extraction of oxygen (CEO(2)) levels were measured on day 1, 3, 5 and 7, as well as the level of CRP in the peripheral blood. In the control group, the level of JVBL decreased as compared with the level at day 1, however, no statistically significant differences were observed (P>0.05). By contrast, the observation group exhibited a significant reduction in the level of JVBL (P<0.05), which was also significantly lower compared with the control group (P<0.05). Statistically significant differences were observed between the two groups with regard to SjvO(2), AVDO(2) and CEO(2) on day 3, 5 and 7. The CRP levels in the two groups increased and peaked on day 3. However, the CRP level in the observation group significantly decreased on day 5 (35.27±15.18 mg/l) and day 7 (22.65±10.48 mg/l), which was lower compared with the control group (56.19±13.24 mg/l and 47.36±15.73 mg/l, respectively); statistically significant differences were observed (P<0.05). Therefore, ulinastatin effectively improved cerebral oxygen metabolism and reduced the CRP level in patients with sTBI. D.A. Spandidos 2014-06 2014-04-04 /pmc/articles/PMC4043583/ /pubmed/24926366 http://dx.doi.org/10.3892/etm.2014.1666 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
HUI, LEI
SHEN, FAZHENG
CHANG, HAIGANG
LI, XIANGSHENG
GAO, GUOJUN
MA, JIWEI
Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury
title Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury
title_full Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury
title_fullStr Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury
title_full_unstemmed Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury
title_short Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury
title_sort effects of ulinastatin on cerebral oxygen metabolism and crp levels in patients with severe traumatic brain injury
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043583/
https://www.ncbi.nlm.nih.gov/pubmed/24926366
http://dx.doi.org/10.3892/etm.2014.1666
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