Cargando…
BIIB021, an Hsp90 inhibitor, effectively kills a myelodysplastic syndrome cell line via the activation of caspases and inhibition of PI3K/Akt and NF-κB pathway proteins
The novel orally available inhibitor of the molecular chaperone heat shock protein 90 (Hsp90), BIIB021, induces the apoptosis of various types of tumor cell in vitro and in vivo. However, the effects and mechanisms of this agent on myelodysplastic syndrome (MDS) cell lines remain unknown. The aim of...
Autores principales: | LIN, SHENGYUN, LI, JING, ZHOU, WENJING, QIAN, WENBIN, WANG, BO, CHEN, ZHI |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043628/ https://www.ncbi.nlm.nih.gov/pubmed/24926340 http://dx.doi.org/10.3892/etm.2014.1651 |
Ejemplares similares
-
The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas
por: Suzuki, Michio, et al.
Publicado: (2015) -
BIIB093 (intravenous glibenclamide) for the prevention of severe cerebral edema
por: Griepp, Daniel W., et al.
Publicado: (2021) -
The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis
por: Li, Xiaoping, et al.
Publicado: (2013) -
New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB
por: Tu, Rong-Hui, et al.
Publicado: (2021) -
Hsp90 Is Involved in Apoptosis of Candida albicans by Regulating the Calcineurin-Caspase Apoptotic Pathway
por: Dai, BaoDi, et al.
Publicado: (2012)