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Longevity pathways and memory aging
The aging process has been associated with numerous pathologies at the cellular, tissue, and organ level. Decline or loss of brain functions, including learning and memory, is one of the most devastating and feared aspects of aging. Learning and memory are fundamental processes by which animals adju...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044971/ https://www.ncbi.nlm.nih.gov/pubmed/24926313 http://dx.doi.org/10.3389/fgene.2014.00155 |
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author | Gkikas, Ilias Petratou, Dionysia Tavernarakis, Nektarios |
author_facet | Gkikas, Ilias Petratou, Dionysia Tavernarakis, Nektarios |
author_sort | Gkikas, Ilias |
collection | PubMed |
description | The aging process has been associated with numerous pathologies at the cellular, tissue, and organ level. Decline or loss of brain functions, including learning and memory, is one of the most devastating and feared aspects of aging. Learning and memory are fundamental processes by which animals adjust to environmental changes, evaluate various sensory signals based on context and experience, and make decisions to generate adaptive behaviors. Age-related memory impairment is an important phenotype of brain aging. Understanding the molecular mechanisms underlying age-related memory impairment is crucial for the development of therapeutic strategies that may eventually lead to the development of drugs to combat memory loss. Studies in invertebrate animal models have taught us much about the physiology of aging and its effects on learning and memory. In this review we survey recent progress relevant to conserved molecular pathways implicated in both aging and memory formation and consolidation. |
format | Online Article Text |
id | pubmed-4044971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40449712014-06-12 Longevity pathways and memory aging Gkikas, Ilias Petratou, Dionysia Tavernarakis, Nektarios Front Genet Genetics The aging process has been associated with numerous pathologies at the cellular, tissue, and organ level. Decline or loss of brain functions, including learning and memory, is one of the most devastating and feared aspects of aging. Learning and memory are fundamental processes by which animals adjust to environmental changes, evaluate various sensory signals based on context and experience, and make decisions to generate adaptive behaviors. Age-related memory impairment is an important phenotype of brain aging. Understanding the molecular mechanisms underlying age-related memory impairment is crucial for the development of therapeutic strategies that may eventually lead to the development of drugs to combat memory loss. Studies in invertebrate animal models have taught us much about the physiology of aging and its effects on learning and memory. In this review we survey recent progress relevant to conserved molecular pathways implicated in both aging and memory formation and consolidation. Frontiers Media S.A. 2014-06-04 /pmc/articles/PMC4044971/ /pubmed/24926313 http://dx.doi.org/10.3389/fgene.2014.00155 Text en Copyright © 2014 Gkikas, Petratou and Tavernarakis. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Gkikas, Ilias Petratou, Dionysia Tavernarakis, Nektarios Longevity pathways and memory aging |
title | Longevity pathways and memory aging |
title_full | Longevity pathways and memory aging |
title_fullStr | Longevity pathways and memory aging |
title_full_unstemmed | Longevity pathways and memory aging |
title_short | Longevity pathways and memory aging |
title_sort | longevity pathways and memory aging |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044971/ https://www.ncbi.nlm.nih.gov/pubmed/24926313 http://dx.doi.org/10.3389/fgene.2014.00155 |
work_keys_str_mv | AT gkikasilias longevitypathwaysandmemoryaging AT petratoudionysia longevitypathwaysandmemoryaging AT tavernarakisnektarios longevitypathwaysandmemoryaging |