Discovery of Triterpenoids as Reversible Inhibitors of α/β-hydrolase Domain Containing 12 (ABHD12)

BACKGROUND: α/β-hydrolase domain containing (ABHD)12 is a recently discovered serine hydrolase that acts in vivo as a lysophospholipase for lysophosphatidylserine. Dysfunctional ABHD12 has been linked to the rare neurodegenerative disorder called PHARC (polyneuropathy, hearing loss, ataxia, retinosi...

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Detalles Bibliográficos
Autores principales: Parkkari, Teija, Haavikko, Raisa, Laitinen, Tuomo, Navia-Paldanius, Dina, Rytilahti, Roosa, Vaara, Miia, Lehtonen, Marko, Alakurtti, Sami, Yli-Kauhaluoma, Jari, Nevalainen, Tapio, Savinainen, Juha R., Laitinen, Jarmo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045134/
https://www.ncbi.nlm.nih.gov/pubmed/24879289
http://dx.doi.org/10.1371/journal.pone.0098286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045134/
https://www.ncbi.nlm.nih.gov/pubmed/24879289
http://dx.doi.org/10.1371/journal.pone.0098286

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