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Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects
There is an urgent need for new, safer, and effective treatments for the diseases caused by the protozoan parasites Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. In the search for more effective drugs to treat these ‘neglected diseases’ researchers have chosen to reassess the therapeuti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045206/ https://www.ncbi.nlm.nih.gov/pubmed/24776300 http://dx.doi.org/10.1016/j.pt.2014.04.003 |
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author | Patterson, Stephen Wyllie, Susan |
author_facet | Patterson, Stephen Wyllie, Susan |
author_sort | Patterson, Stephen |
collection | PubMed |
description | There is an urgent need for new, safer, and effective treatments for the diseases caused by the protozoan parasites Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. In the search for more effective drugs to treat these ‘neglected diseases’ researchers have chosen to reassess the therapeutic value of nitroaromatic compounds. Previously avoided in drug discovery programs owing to potential toxicity issues, a nitro drug is now being used successfully as part of a combination therapy for human African trypanosomiasis. We describe here the rehabilitation of nitro drugs for the treatment of trypanosomatid diseases and discuss the future prospects for this compound class. |
format | Online Article Text |
id | pubmed-4045206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40452062014-06-06 Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects Patterson, Stephen Wyllie, Susan Trends Parasitol Review There is an urgent need for new, safer, and effective treatments for the diseases caused by the protozoan parasites Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. In the search for more effective drugs to treat these ‘neglected diseases’ researchers have chosen to reassess the therapeutic value of nitroaromatic compounds. Previously avoided in drug discovery programs owing to potential toxicity issues, a nitro drug is now being used successfully as part of a combination therapy for human African trypanosomiasis. We describe here the rehabilitation of nitro drugs for the treatment of trypanosomatid diseases and discuss the future prospects for this compound class. Elsevier Science 2014-06 /pmc/articles/PMC4045206/ /pubmed/24776300 http://dx.doi.org/10.1016/j.pt.2014.04.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Patterson, Stephen Wyllie, Susan Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects |
title | Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects |
title_full | Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects |
title_fullStr | Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects |
title_full_unstemmed | Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects |
title_short | Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects |
title_sort | nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045206/ https://www.ncbi.nlm.nih.gov/pubmed/24776300 http://dx.doi.org/10.1016/j.pt.2014.04.003 |
work_keys_str_mv | AT pattersonstephen nitrodrugsforthetreatmentoftrypanosomatiddiseasespastpresentandfutureprospects AT wylliesusan nitrodrugsforthetreatmentoftrypanosomatiddiseasespastpresentandfutureprospects |