Identifying biological pathways that underlie primordial short stature using network analysis

Mutations in CUL7, OBSL1 and CCDC8, leading to disordered ubiquitination, cause one of the commonest primordial growth disorders, 3-M syndrome. This condition is associated with i) abnormal p53 function, ii) GH and/or IGF1 resistance, which may relate to failure to recycle signalling molecules, and...

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Detalles Bibliográficos
Autores principales: Hanson, Dan, Stevens, Adam, Murray, Philip G, Black, Graeme C M, Clayton, Peter E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045235/
https://www.ncbi.nlm.nih.gov/pubmed/24711643
http://dx.doi.org/10.1530/JME-14-0029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045235/
https://www.ncbi.nlm.nih.gov/pubmed/24711643
http://dx.doi.org/10.1530/JME-14-0029

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