SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres

SHetA2 is a small molecule flexible heteroarotinoid (Flex-Het) with promising cancer prevention and therapeutic activity. Extensive preclinical testing documented lack of SHetA2 toxicity at doses 25 to 150 fold above effective doses. Knowledge of the SHetA2 molecular target(s) that mediate(s) the me...

Descripción completa

Detalles Bibliográficos
Autores principales: Benbrook, Doris Mangiaracina, Nammalwar, Baskar, Long, Andrew, Matsumoto, Hiroyuki, Singh, Anil, Bunce, Richard A., Berlin, K. Darrell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045313/
https://www.ncbi.nlm.nih.gov/pubmed/24254390
http://dx.doi.org/10.1007/s10637-013-0041-x

Ejemplares similares

Ejemplares similares